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Intelligent tutoring systems that utilize Bayesian Knowledge Tracing have achieved the ability to accurately predict student performance not only within the intelligent tutoring system, but on paper post-tests outside of the system. Recent work has suggested that contextual estimation of student guessing and slipping leads to better prediction within the(More)
The literature on the cost-effectiveness of statin drugs in primary prevention of coronary heart disease is complex. The objective of this study is to compare the disparate results of recent cost-effectiveness analyses of statins. We conducted a systematic review of the literature on statin cost-effectiveness. The four studies that met inclusion criteria(More)
This study examines the impact of integrating worked examples into a Cognitive Tutor for genetics problem solving, and whether a genetics process modeling task can help prepare students for explaining worked examples and solving problems. Students participated in one of four conditions in which they engaged in either: (1) process modeling followed by(More)
In this paper, we examine the impact of three learning activities designed to foster more robust learning in a Genetics Cognitive Tutor module on pedigree analysis problem solving, in an experimental study. The three activities are (1) interleaved worked examples with student explanations ; (2) enhanced feedback with tutor-provided explanations of problem(More)
This study examines how accurately individual student differences in learning can be predicted from prior student learning activities. Bayesian Knowledge Tracing (BKT) predicts learner performance well and has often been employed to implement cognitive mastery. Standard BKT individualizes parameter estimates for knowledge components, but not for learners.(More)
Extraskeletal myxoid chondrosarcoma (EMC) is a soft tissue malignancy characterized by specific chromosomal abnormalities involving the TEC gene. This disease has historically been considered largely indolent both histologically and clinically. Rarer subsets of EMC exist that demonstrate aggressive histopathologic features and clinical behavior, though it(More)
BACKGROUND Poor accrual is a significant barrier to the successful completion of oncology clinical trials; half of all phase 3 oncology trials close due to insufficient accrual. Timely access to accrual data fosters an understanding of successful trial design and can be used to inform the design of new clinical trials prospectively. Accrual statistics are(More)
This paper describes two types of Conceptually Grounded Learning Activities designed to foster more robust learning in the Genetics Cognitive Tutor: interleaved worked examples and genetic-process reasoning scaffolds. We report three empirical studies that evaluate the impact of these learning activities on three diverse genetics problem-solving topics in(More)
Background. Recent literature has associated hepatitis C virus with the development of non-Hodgkin lymphoma. Hepatitis C virus infection appears to promote lymphoproliferation, providing a plausible mechanism for a causative association; however, despite prior reports of patients with comorbid hepatitis C infection and Waldenström macroglobulinemia, the(More)