Aaron Mitchell

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To analyze the function of ciliary polycystic kidney disease 2 (PKD2) and its relationship to intraflagellar transport (IFT), we cloned the gene encoding Chlamydomonas reinhardtii PKD2 (CrPKD2), a protein with the characteristics of PKD2 family members. Three forms of this protein (210, 120, and 90 kD) were detected in whole cells; the two smaller forms are(More)
It has come to our attention that approximately 35% of >100 published microarray datasets, where transcript levels were compared between two different strains, exhibit some form of chromosome-specific bias. While some of these arose from the use of strains whose aneuploidies were not known at the time, in a worrisome number of cases the recombinant strains(More)
Development of human embryonic stem cell (hESC)-based therapy requires derivation of in vitro expandable cell populations that can readily differentiate to specified cell types and engraft upon transplantation. Here, we report that hESCs can differentiate into skeletal muscle cells without genetic manipulation. This is achieved through the isolation of(More)
INBOUNDS is a real-time network based intrusion detection system being developed at Ohio University. INBOUNDS detects suspicious behavior by scrutinizing network information generated by TCPTrace [9] (a traffic analysis tool) and host data gathered by the monitors of DeSiDeRaTa [23-27] (dynamic, real-time resource management middleware). The use of these(More)
The global Internet has made real-time computer systems worldwide vulnerable to an ever-changing array of attacks for which current defense mechanisms are insufficient. In order to combat intruders in this new environment new techniques must be developed that enable decision makers to detect unusual behavior in their systems, correlate anomalies into(More)
The intraflagellar transport (IFT) system was first identified in situ by electron microscopy in thin sections of plastic-embedded flagella as linear arrays of electrondense particles, located between the B tubules of the outer doublets and the flagellar membrane. These arrays of particles are referred to as IFT trains. Upon membrane rupture, IFT trains are(More)
Background. Recent literature has associated hepatitis C virus with the development of non-Hodgkin lymphoma. Hepatitis C virus infection appears to promote lymphoproliferation, providing a plausible mechanism for a causative association; however, despite prior reports of patients with comorbid hepatitis C infection and Waldenström macroglobulinemia, the(More)
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