Aaron M. Freilich

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c-Jun N-terminal kinase (JNK) is activated when T-lymphocytes are stimulated jointly through the T-cell receptor (TCR) and CD28, and it contributes to T-cell activation and IL-2 production through phosphorylation of transcription factors, including c-Jun. We performed in vitro kinase assays on JNK in CD4(+) T-cells, from young and old mice, activated by(More)
BACKGROUND Osteochondritis dissecans (OCD) of the capitellum is a condition most commonly seen in adolescents involved in repetitive overhead sports and can profoundly affect ability to return to play and long-term elbow function. Treatment of large, unstable defects in the elbow with osteochondral autograft plug transfer has not been adequately studied. (More)
Intra-articular ganglia of the knee occur infrequently, with an overall incidence estimated to be from 0.2 to 1.9%. To date, the youngest patient reported with an intra-articular ganglion was an adolescent. In this paper, we describe a 2-year-old patient with a massive intra-articular knee cyst and an aberrant anterior cruciate ligament (ACL) origin. The(More)
As techniques have improved, primary repair of flexor tendon lacerations, including zone II injuries, have become more common. Secondary reconstruction, whether in 1 or 2 stages, remains an important and useful technique for the treatment of these injuries. Current indications and methods, including delayed treatment and 1-stage and 2-stage reconstruction,(More)
BACKGROUND Distal humerus fractures commonly require surgical intervention, including open reduction and internal fixation (ORIF) and, more recently in elderly, low-demand individuals, total elbow arthroplasty (TEA). The association of obesity with complications after either of these procedures has not previously been examined. METHODS A national(More)
PURPOSE To determine the relative benefits of an extended flexor carpi radialis (FCR) (eFCR) approach with prophylactic carpal tunnel release at the time of volar plate osteosynthesis for distal radius fracture via a single incision into the traditional volar Henry (VH) approach. METHODS This was a prospective cohort comparison of preoperative and(More)
The flexor tendon system in the finger is complex and can be difficult to treat. Closed injuries to the flexor tendon or pulley system are not uncommon in high-level athletes. Their treatment can be complicated by in-season play, position, and the number of people involved in the patient's care. Injuries can be misdiagnosed as "sprains" or unreported by(More)
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