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OBJECTIVE To test the cognitive reserve hypothesis by examining the effect of education on memory decline during the preclinical course of dementia. BACKGROUND Low education is a well known risk factor for Alzheimer disease (AD). Persons destined to develop AD experience an accelerated rate of decline in cognitive ability, particularly in memory. The(More)
OBJECTIVE To study the influence of leisure activity participation on risk of development of amnestic mild cognitive impairment (aMCI). METHODS The authors examined the relationship between baseline level of participation in leisure activities and risk of aMCI in a prospective cohort of 437 community-residing subjects older than 75 years, initially free(More)
OBJECTIVES To study the epidemiology of gait disorders in community-residing older adults and their association with death and institutionalization. DESIGN Community-based cohort study. SETTING Bronx County and the research center at Albert Einstein College of Medicine. PARTICIPANTS The Einstein Aging study recruited 488 adults aged 70 to 99 between(More)
Frontal gaits (FG) and parkinsonian gaits (PG) are common neurological gait abnormalities in older adults. It may be difficult to distinguish these gaits as they share common clinical characteristics such as unsteadiness, slowing, and shuffling. Of 488 community-residing subjects in an aging study, 11 were diagnosed with FG and 9 with PG at baseline(More)
Clinicians often encounter patients whose neurologic attacks appear to cluster. In a daily diary study, the authors explored whether clustering is a true phenomenon in epilepsy and can be identified in the clinical setting. Nearly half the subjects experienced at least one episode of three or more seizures in 24 hours; 20% also met a statistical clustering(More)
There is some evidence of retroviral infection in ALS. A randomized, double-blind, placebo-controlled trial of indinavir in ALS was performed to assess safety and efficacy trends. Nephrolithiasis and gastrointestinal side effects were frequent with indinavir treatment. Group differences in the rate of decline were not significant between the groups for the(More)
OBJECTIVES To examine the association between blood pressure (BP) levels and long-term stroke outcomes in elderly stroke survivors. DESIGN Observational study. SETTING The Cardiovascular Health Study (CHS) of 5,888 community-dwelling adults. PARTICIPANTS Two hundred fifty-four adults aged 65 and older (mean age 78.6) who sustained a nonfatal first(More)
Morphologic features of Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) overlap. No single phenotypic marker or molecular abnormality is pathognomonic. We tested a panel of 8 germinal center (GC) and activated B-cell (ABC) markers for their ability to separate BL and DLBCL. We diagnosed 16 BL and 39 DLBCL cases from 21 patients with AIDS and(More)
Based on gene expression profiling, diffuse large B-cell lymphomas arising in immunocompetent patients can be divided into germinal center and activated B-cell types. Since little is known about acquired immunodeficiency syndrome associated diffuse large B-cell lymphomas, we tested whether the protein expression of germinal center and activated B-cell(More)