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Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues
The role of the cellular microenvironment in enabling metazoan tissue genesis remains obscure. Ctenophora has recently emerged as one of the earliest-branching extant animal phyla, providing a uniqueExpand
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A unique covalent bond in basement membrane is a primordial innovation for tissue evolution
Significance The evolution of multicellular animals from single-celled ancestors was one of the most significant transitions of life on earth. The emergence of larger, more complex animals able toExpand
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The triple helix of collagens – an ancient protein structure that enabled animal multicellularity and tissue evolution
ABSTRACT The cellular microenvironment, characterized by an extracellular matrix (ECM), played an essential role in the transition from unicellularity to multicellularity in animals (metazoans), andExpand
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Unicellular ancestry and mechanisms of diversification of Goodpasture antigen–binding protein
The emergence of the basement membrane (BM), a specialized form of extracellular matrix, was essential in the unicellular transition to multicellularity. However, the mechanism is unknown.Expand
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A chloride ring is an ancient evolutionary innovation mediating the assembly of the collagen IV scaffold of basement membranes
Collagen IV scaffold is a principal component of the basement membrane (BM), a specialized extracellular matrix that is essential for animal multicellularity and tissue evolution. Scaffold assemblyExpand
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Proterometra macrostoma (Faust) (Trematoda: Azygiidae): Further Studies on Strains at North Elkhorn Creek, Scott County, Kentucky
Abstract The objectives of the present study were (1) to compare the frequency of Proterometra macrostoma (Faust) strains and the number of single vs. multiple strain infections in snails, ElimiaExpand
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