Aaron J. Stupica

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OBJECTIVE Despite the role that extracellular matrix (ECM) plays in vascular signaling, little is known of the complex structural arrangement between specific ECM proteins and vascular smooth muscle cells. Our objective was to examine the hypothesis that adventitial elastin fibers are dominant in vessels subject to longitudinal stretch. METHODS AND(More)
Abstract  β1-Subunits enhance the gating properties of large-conductance Ca(2+)-activated K(+) channels (BKCa) formed by α-subunits. In arterial vascular smooth muscle cells (VSMCs), β1-subunits are vital in coupling SR-generated Ca(2+) sparks to BKCa activation, affecting contractility and blood pressure. Studies in cremaster and cerebral VSMCs show(More)
Received on: April 19, 2011; final version accepted on: September 20, 2011. From the Dalton Cardiovascular Research Center (P.S.C., S.R.E., A.J.S., Z.N., M.L., L.A.M.-L., Y.Y., M.J.D., G.A.M., M.A.H.) and Departments of Biological Engineering (S.R.E., A.J.S., M.J.D., G.A.M., M.A.H.) and Medical Pharmacology and Physiology (L.A.M.-L., M.J.D., G.A.M.,(More)
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