Aaron J Mattingly
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Salivary gland development and disease.
- Aaron J Mattingly, Jennifer K Finley, S. Knox
- Biology, Medicine
- Wiley interdisciplinary reviews. Developmental…
- 1 November 2015
Mammalian salivary glands synthesize and secrete saliva via a vast interconnected network of epithelial tubes attached to secretory end units. The extensive morphogenesis required to establish this… Expand
Salivary glands regenerate after radiation injury through SOX2‐mediated secretory cell replacement
- E. Emmerson, Alison J May, +7 authors S. Knox
- Medicine, Biology
- EMBO molecular medicine
- 15 January 2018
Salivary gland acinar cells are routinely destroyed during radiation treatment for head and neck cancer that results in a lifetime of hyposalivation and co‐morbidities. A potential regenerative… Expand
A novel antagonist of p75NTR reduces peripheral expansion and CNS trafficking of pro-inflammatory monocytes and spares function after traumatic brain injury
BackgroundTraumatic brain injury (TBI) results in long-term neurological deficits, which may be mediated in part by pro-inflammatory responses in both the injured brain and the circulation.… Expand
Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes
- Julie P Saiki, H. Cao, +15 authors D. Mochly-Rosen
- Proceedings of the National Academy of Sciences
- 24 May 2018
Significance Radiation therapy for head and neck cancer often leads to dry mouth, a debilitating condition that affects speaking, swallowing, and other functions related to quality of life. Since… Expand
Increased Gs Signaling in Osteoblasts Reduces Bone Marrow and Whole-Body Adiposity in Male Mice.
Bone is increasingly recognized as an endocrine organ that can regulate systemic hormones and metabolism through secreted factors. Although bone loss and increased adiposity appear to be linked… Expand