Aaron C. Hamilton

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187 forested. C. oenanthe is still at risk in these areas, since its preferred habitat is also sought after by rice-farmer tenants. Perhaps of note is that C. oenanthe near the banks of the Río Mayo differs in color from populations of C. oenanthe in the Aguaruna territory to the northeast. If conservation efforts intend to protect both color morphs, then(More)
A time-resolved fluorescence resonance energy transfer (TR-FRET) detection method based on the formation of a PDZ domain.peptide ligand complex has been developed for enzymatic assays as an alternative to immuno-based detection strategies. The enzyme substrate is a "masked" biotinylated PDZ domain peptide ligand containing the consensus sequence(More)
The Salmonella typhimurium LT2 sialidase (neuraminidase, EC structural gene, nanH, has been cloned and sialidase overproduced from multicopy plasmids in Escherichia coli. Sialidase expression was regulated positively by cAMP. In contrast, certain Tn1000 insertions located upstream of nanH coding sequences reduced sialidase activity. A nanH(More)
Bcl-2 and Bcl-X(L) belong to a family of proteins overexpressed in a variety of human cancers which inhibit apoptosis in response to a number of stimuli including chemotherapeutic agents and ionizing radiation. To better understand the role of these polypeptides in modulating the response of cancer cells to ionizing radiation we used cell lines that were(More)
Advocates for individuals with severe and long-term physical disabilities have lobbied aggressively in the U.S. and Canada for the implementation of Independent Provider Care (IPC). In this model of home support service delivery, the client assumes sole responsibility for the management and scheduling of his or her personal care and home support. This(More)
We have recently described a biochemical detection method for peptide products of enzymatic reactions based on the formation of PDZ domain*peptide ligand complexes. The product sensor is based on using masked or cryptic PDZ domain peptide ligands as enzyme substrates. Upon enzymatic processing, a PDZ-binding motif is exposed, and the product sequence bound(More)
BACKGROUND Defensive medicine represents one cause of economic losses in healthcare. Studies that measured its cost have produced conflicting results. OBJECTIVE To directly measure the proportion of primary care costs attributable to defensive medicine. RESEARCH DESIGN AND METHODS Six-week prospective study of primary care physicians from four(More)
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