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BACKGROUND There is current expansion of newborn screening (NBS) programs to include lysosomal storage disorders because of the availability of treatments that produce an optimal clinical outcome when started early in life. OBJECTIVE To evaluate the performance of a multiplex-tandem mass spectrometry (MS/MS) enzymatic activity assay of 6 lysosomal enzymes(More)
In a study of a sample of 317 conceptional basal body temperature (BBT) curves obtained from normal women, the authors have applied new definitions of prematurity and postmaturity which take into account the time of ovulation. They were thus able to estimate (1) the error rates associated with the classical definitions-incorrect classification as pre- or(More)
Human placental lactogen (HPL) was measured in 525 serum samples from 144 pregnant women and related to smoking habits and the birth weight of their infants. Women smoking during pregnancy were found to have a level of HPL significantly lower than the non-smokers (p less than 0.05). A significant correlation between HPL and birth weight was found (r=0.38);(More)
In studying the BBT curves of 433 conceptional cycles, no evidence was found of any correlation between duration of gestation counted from "zero" day, the last day of the hypothermic phase, and various parameters measuring durations or temperatures evaluated from the curves. There is, in particular, no positive correlation with the duration of the(More)
In this data article we provide a detailed standard operating procedure for performing a tandem mass spectrometry, multiplex assay of 6 lysosomal enzymes for newborn screening of the lysosomal storage diseases Mucopolysaccharidosis-I, Pompe, Fabry, Niemann-Pick-A/B, Gaucher, and Krabbe, (Elliott, et al., 2016) [1]. We also provide the mass spectrometry peak(More)
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