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  • Ashvinikumar V. Gavai, Claude A. Quesnelle, +35 authors Francis Y F Lee
  • Biology, Medicine
  • ACS medicinal chemistry letters
  • 2015 (First Publication: 14 May 2015)
  • Structure-activity relationships in a series of (2-oxo-1,4-benzodiazepin-3-yl)-succinamides identified highly potent inhibitors of γ-secretase mediated signaling of Notch1/2/3/4 receptors. On theContinue Reading
  • Mark E. Salvati, Aaron Balog, +16 authors Gamini Chandrasena
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2008 (First Publication: 1 March 2008)
  • A novel series of [2.2.1]-oxabicyclo imide-based compounds were identified as potent antagonists of the androgen receptor. Molecular modeling and iterative drug design were applied to optimize thisContinue Reading