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  • J M Lehr, Secretary A M Dawson Larsen, +26 authors Standards Activities
  • 2007
The IEEE Nuclear and Plasma Sciences Society is an organization, within the framework of the IEEE, of members with principal professional interest in the field of plasma science. All members of the IEEE are eligible for membership in the Society and will receive this TRANSACTIONS upon payment of the annual Society membership fee of $25.00 plus an annual(More)
This report describes recommended techniques for radiopharmaceutical biodistribution data acquisition and analysis in human subjects to estimate radiation absorbed dose using the Medical Internal Radiation Dose (MIRD) schema. The document has been prepared in a format to address two audiences: individuals with a primary interest in designing clinical trials(More)
UNLABELLED Renal toxicity associated with small-molecule radionuclide therapy has been shown to be dose-limiting for many clinical studies. Strategies for maximizing dose to the target tissues while sparing normal critical organs based on absorbed dose and biologic response parameters are commonly used in external-beam therapy. However, radiopharmaceuticals(More)
A number of factors influence the accuracy of estimation of source volume with single-photon emission computed tomography (SPECT) imaging. This study investigated the role of a number of factors including system spatial resolution (which includes the influence of low-pass filters applied to suppress noise), source size and shape, and voxel size in(More)
Severe hypertension causes global and regional changes in myocardial perfusion and substrate utilization. Regional perfusion and fatty acid utilization were evaluated by dual-tracer autoradiography in normotensive and hypertensive rats of the Dahl strain. The regional distributions of perfusion and fatty acid utilization were homogeneous in normotensive(More)
The potential of alpha-particle emitters to treat cancer has been recognized since the early 1900s. Advances in the targeted delivery of radionuclides and radionuclide conjugation chemistry, and the increased availability of alpha-emitters appropriate for clinical use, have recently led to patient trials of radiopharmaceuticals labeled with alpha-particle(More)
We have synthesized 90Y-labeled immunotoxin (IT) containing ricin A chain and C110 anti-carcinoembryonic antigen monoclonal antibody (MAb) to produce a therapeutic immunoconjugate for human colon cancer. The C110 IT was labeled with 90Y via a benzylisothiocyanate derivative of diethylenetriaminepentaacetic acid. The efficiency of 90Y labeling was(More)
Quantitative whole-body autoradiography (WBAR) was used to study the biodistribution of goat anti-carcinoembryonic antigen and normal goat IgG, each labeled with 125I, in hamsters bearing the carcinoembryonic antigen-producing GW-39 human colonic carcinoma xenograft. Comparisons between computer-assisted videodensitometric profiles of WBARs and tissue(More)
Data published by others have shown that thiouracil (TU) is taken up selectively during melanin synthesis following trace doses of labeled TU. The concentration in newly forming mel anin has been attributed to the incorporation of TU as a "false precursor" in the biosynthetic pathway of melanin. Information made available previously has been in terms of(More)