Aaron A Cook

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alphavbeta8 Integrin is highly expressed in the vertebrate CNS, and mice lacking the alphav or beta8 genes develop cerebral hemorrhage due to defective interactions between blood vessels and alphavbeta8-expressing neural cells. Although alphavbeta8 binds many of the same extracellular matrix protein ligands as other integrins, very little is known about the(More)
OBJECTIVE To present patients with stuttering speech in association with stroke. DESIGN Case series with follow-up for 5 years, or until the stuttering resolved. SETTING University and community hospital neurology wards, and ambulatory neurology clinics. PATIENTS Four patients who developed stuttering speech in association with an acute ischemic(More)
The dynamic regulation of ERK1 and -2 (ERK1/2) is required for precise signal transduction controlling cell proliferation, differentiation, and survival. However, the underlying mechanisms regulating the activation of ERK1/2 are not completely understood. In this study, we show that phosphorylation of RasGRP2, a guanine nucleotide exchange factor (GEF),(More)
Both humoral and cell-mediated autoimmune mechanisms have been implicated in the pathogenesis of Guillain-Barré syndrome (GBS). Therefore, its occurrence in severely immunocompromised patients is not expected. We identified 3 severely immunocompromised patients who developed GBS. Two of the 3 patients had acquired immunodeficiency syndrome with CD4 counts(More)
Handcuff neuropathy was the most common neurologic problem acquired by U.S. prisoners of war during Operation Desert Storm. Neurologic deficits were exclusively sensory in all those affected and began to resolve shortly after their release from captivity. Some individuals expressed concern that these injuries could be career-threatening. One of those(More)
In addition to mutations in ITG2B or ITGB3 genes that cause defective αIIbβ3 expression and/or function in Glanzmann's thrombasthenia patients, platelet dysfunction can be a result of genetic variability in proteins that mediate inside-out activation of αIIbβ3 The RASGRP2 gene is strongly expressed in platelets and neutrophils, where its encoded protein(More)
United States prisoners of war had to endure a variety of medical problems during Operations Desert Shield and Desert Storm. All but one of the prisoners suffered some form of injury or illness. Orthopedic injuries were most common. Hematologic, dermatologic, neurologic, and infectious disorders were also noted. Some injuries were combat-related and others(More)
During Operation Desert Storm, 21 United States and 2 Italian military personnel were held in Iraq as prisoners of war. Of these, 18 had ejected from fixed-wing, ejection seat-equipped, combat aircraft prior to their capture. Of the 18, 6 (33%) had sustained vertebral fractures; 4 of these were compression fractures. This fracture rate is comparable to that(More)
  • A A Cook
  • Environmental science & technology
  • 1986
is nevertheless a luxury. They argue that although a high level of environmental quality is desirable, pursuing this goal can damage the economy. We must therefore always be on guard against spending too much on wasteful environmental programs-wasteful because they destroy jobs, bankrupt businesses, decrease productivity, and produce a host of other real or(More)