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Aspartic Peptidase Inhibitors: Implications in Drug Development
- C. Dash, Aarohi Kulkarni, B. Dunn, M. Rao
- Biology, Medicine
- Critical reviews in biochemistry and molecular…
- 1 January 2003
The last decade has witnessed an effervescence of research interest in the development of potent inhibitors of various aspartic peptidases. As an enzyme family, aspartic peptidases are relatively a… Expand
Bacterial enzyme mediated biosynthesis of gold nanoparticles.
- Atul A. Bharde, Aarohi Kulkarni, M. Rao, Asmita Prabhune, M. Sastry
- Materials Science, Medicine
- Journal of nanoscience and nanotechnology
- 1 December 2007
Development of synthesis methods for anisotropic metal nanoparticles is of considerable interest due to their remarkable optoelectronic properties. Various shapes ranging from rods to cubes to… Expand
Frontiers in Drug Design and Discovery
Differential elicitation of an aspartic protease inhibitor: Regulation of endogenous protease and initial events in germination in seeds of Vigna radiata
Plant aspartic proteases are of recent origin with their physiological significance in crucial processes emerging. Reports on the significance of aspartic protease inhibitors and their endogenous… Expand
pH induced structural alterations in an aspartic protease from Vigna radiata indicating an alkali induced molten globule state.
- Aarohi Kulkarni, S. Gaikwad, M. Rao
- Medicine, Chemistry
- International journal of biological…
- 1 November 2008
pH-dependent transitions in secondary and tertiary structure are described for a plant aspartic protease from Vigna radiata. The enzyme was pH stable with pH optima of 3.0. The Lineweaver Burk… Expand
Biochemical characterization of an aspartic protease from Vigna radiata: Kinetic interactions with the classical inhibitor pepstatin implicating a tight binding mechanism.
Aspartic proteases are the focus of recent research interest in understanding the physiological importance of this class of enzymes in plants. This is the first report of an aspartic protease from… Expand
Administration of Streptococcus bovis isolated from sheep rumen digesta on rumen function and physiology as evaluated in a rumen simulation technique system
- Durgadevi Aphale, Aamod Natu, Sharad Laldas, Aarohi Kulkarni
- Medicine, Biology
- Veterinary world
- 1 September 2019
Background and Aim: Little information about the stability and changes of sheep ruminal microbiota due to pathogen intervention in the rumen simulation technique (RUSITEC) is available. This study… Expand
Modifications and optimization of manual methods for polymerase chain reaction and 16S rRNA gene sequencing quality community DNA extraction from goat rumen digesta
Background and Aim: A critical prerequisite for studying rumen microbial community by high throughput molecular biology methods is good quality community DNA. Current methods of extraction use kits… Expand