Aakash Deep

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A series of new γ-aminobutyric acid (GABA) derivatives was obtained from 4-(1,3-dioxoisoindolin-2-yl)butanoic acid by coupling it with various substituted amines by using DCC as coupling reagent. The compound 3 was synthesized by treating GABA and phthalimide at high temperature under anhydrous conditions. All the synthesized compounds were confirmed and(More)
A series of novel N-[5-(arylidene)-2-(aryl)-4-oxo-thiazolidin-3-yl]-4-biphenylcarboxamide derivatives was synthesized and evaluated for analgesic and anti-inflammatory activity. In this study, biphenyl-4-carboxylic acid hydrazide was converted to the corresponding aryl hydrazones using aryl aldehydes in the presence of catalytic amount of glacial acetic(More)
In the present investigation, a series of new Mannich bases were prepared by the reaction of 2-ethoxybenzaldehyde with isoniazid to form acid hydrazone (3a). Further, C-Mannich bases of the above acid hydrazone were prepared by aminomethylation with formaldehyde and substituted secondary amines (3b–3k). The structures of newly synthesized compounds were(More)
AIM Aim of this work was to design and identify some S-adenosyl-L-homocysteine (SAH) analogs as inhibitors of S-adenosyl-L-methionine-dependent methyltransferase (MTase) protein using computational approaches. INTRODUCTION According to the current scenario the dengue has been a global burden. The people are being killed by dengue virus in an abundant(More)
Plan: Anti-anxiety activity of Gloriosa superba Linn. Prologue: Gloriosa supberba Linn. (Family: Liliaceae) is widely used as a medicinal plant. Gloriosa superba Linn. has several therapeutic applications including antinflammatory, anthelmintic, abotifacient, oxytocic, analgesic antimicrobial and mutagenic activities 1-3. The petroleum ether and ethanol(More)
Plan: Anti-anxiety activity of Sida rhombifolia Linn. Prologue: Sida rhombifolia commonly called Bala or Atibala is claimed by folklore for various ailments like rheumatism, seminal weakness, and diarrhea. Earlier studies on the ethanolic extract of the roots (SRE) revealed a significant, antioxidant, antimicrobial, anti-inflammatory, hepatoprotective and(More)
A series of (E)-N′-(substituted-benzylidene)isonicotinohydrazide derivatives were synthesized by coupling it with different substituted aldehydes, acetophenone, and benzophenones in presence of absolute ethanol along with catalytic amount of glacial acetic acid. All the synthesized compound were confirmed and characterized by using various spectral(More)
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