A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion bp DNA sequence was generated over 9 months from 27,271,853 high-quality sequence reads (5.11-fold coverage of the genome) from both ends of plasmid clones made from the DNA of five… (More)
The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the approximately 120-megabase euchromatic portion of the… (More)
Knowledge of the critical temperature, T(*), the temperature at which a phase change occurs, greatly improves the efficiency of simulated annealing when used for optimization or inversion. A numerical method of accurately determining T(*) in a relatively short computation time has been developed. This method is used to recover the seismic soundspeed profile… (More)
A combination of two single-molecule techniques has revealed new tertiary interactions in the TPP riboswitch.
Mechanoelectrical transduction by hair cells commences with hair-bundle deflection, which is postulated to tense filamentous tip links connected to transduction channels. Because direct mechanical stimulation of tip links has not been experimentally possible, this hypothesis has not been tested. We have engineered DNA tethers that link superparamagnetic… (More)