AS Carr

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OBJECTIVES The genetic aetiology of osteoarthritis has not yet been elucidated. To enable a well-powered genome-wide association study (GWAS) for osteoarthritis, the authors have formed the arcOGEN Consortium, a UK-wide collaborative effort aiming to scan genome-wide over 7500 osteoarthritis cases in a two-stage genome-wide association scan. Here the(More)
OBJECTIVE To identify osteoarthritis (OA) relevant genes and pathways in damaged and undamaged cartilage isolated from the knees of patients with anteromedial gonarthrosis (AMG) - a specific form of knee OA. DESIGN Cartilage was obtained from nine patients undergoing unicompartmental knee replacement (UKR) for AMG. AMG provides a spatial representation of(More)
People with Cystic Fibrosis have a high risk of MRSA infection. Prevalence has increased from 7% of patients in 2001 to 17.2% of patients in 2005 in the USA (1). It is unclear whether MRSA respiratory infection influences lung function, which antibiotics (if any) should be used to treat MRSA infection and for how long. This study investigates the prevalence(More)
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