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INTRODUCTION We identify the genetic and environmental factors associated to Alzheimer's disease (AD) in a population aged 80 years or greater. METHOD POPULATION STUDIED subjects who participated in the COGMANLLEU study on prevalence of cognitive deterioration in Manlleu (Osona, Central Catalonia). DESIGN nested case control studies. The subjects who(More)
Aged-related spinal cord changes such as neuronal loss have been related to the degree of clinical severity of amyotrophic lateral sclerosis (ALS); morphological data on synapses are, however, wanting. Variations in synaptophysin (Sph) expression in aging and ALS were thus studied at the level of lower motor neurons in 40 controls with non-neurological(More)
In order to identify possible morphological changes which occur in the anterior horn of normal individuals during aging, 40 controls with no neurological disease were studied. Brain and spinal cord tissue was processed according to a brain banking protocol. Controls were grouped according to age in 10 year intervals. Serial sections (20 microm) of formalin(More)
The isoenzyme Mu of glutathione S-transferase (GSTM1) is dominantly inherited, and the prevalence of this isoenzyme in the population is about 60%. The lack of GSTM1 has been linked with cancer risk. The frequency of the phenotypes of this isoenzyme in melanoma (MM) patients (n = 197) is reported here. A significantly higher proportion of individuals in the(More)
INTRODUCTION We want to detect the prevalence of cognitive prevalence deterioration in the elderly population of 80-years-old or older, their grade of deterioration and the causal pathogenic entity. METHOD DESIGN a cross-sectional population study, including a first phase of screening and a second one of diagnosis confirmation. STUDY SUBJECTS a total(More)
Movement disorders (bemichorea-hemiballismus, hemidystonia and isolated tremor) are an uncommon clinical manifestation in ischemic stroke (IS), and their anatomical basis is poorly understood. We analyzed the clinical and neuroimaging characteristics of 22 consecutive patients who bad movement disorders associated with cerebral infarction (MDCI), studied at(More)
Motorneurons which are primarily affected in ALS cannot be sampled during life. Morphological, biochemical, ultrastructural and molecular investigations can be only performed on post-mortem material. No animal model reproduce adequately ALS. All these features and the low ALS incidence and the absence of definite clusters stress the need for brain banking(More)