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Whole cell patch clamp recording from neurones of a slice preparation of the frog optic tectum showed that depolarizing step commands from -70 mV holding potential generated a fast inward current always followed by a fast outward current. The fast outward current was blocked by tetrodotoxin (TTX) or 4-aminopyridine (4-AP), or by replacing external Na+ with(More)
Macroscopic inactivation of A-current was studied in internally perfused Lymnaea neurons under voltage clamp conditions. Inactivation kinetics were satisfactorily described by the sum of two exponentials, suggesting the presence of two type inactivation. The kinetics of recovery from inactivation were exponential. The rate constants of the fast phase of(More)
Wang, Wengang, Jyoti K. Tiwari, Stefania Risso Bradley, Andrey V. Zaykin, and George B. Richerson. Acidosis-stimulated neurons of the medullary raphe are serotonergic. J Neurophysiol 85: 2224–2235, 2001. Neurons of the medullary raphe project widely to respiratory and autonomic nuclei and contain co-localized serotonin, thyrotropin-releasing hormone (TRH),(More)
Frog optic tectum neurones in vitro (under whole cell patch clamp with a Cs(+)-filled electrode) generated, in response to voltage steps negative to -80 mV from -60 mV holding potential, transient inward currents dependent on extracellular Na+ and blocked by tetrodotoxin (TTX). Depolarizing steps from the same holding potential induced conventional, fast(More)
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