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NIsHIE, KEICA,MARLYSWEARYANDARTHURBERCER: Anticonviilsant and convulsant effects of chemically related thiosemicarbazide, thiourea and urea derivatives. J. Pharmac. exp. Ther. 153: 387†" 395, 1966.Eleven thiourea derivativesand their corresponding urea and thiosemicar hazide (TSC) analogues were tested for anticonvulsant properties. Compounds which had o(More)
Alternative splicing of p53 and p73: the novel p53 splice variant p53d is an independent prognostic marker in ovarian cancer Similar to p73, the tumor suppressor gene p53 is subject to alternative splicing. Besides p53DE6 and p53b, we identified p53f, p53d and p53e, arising from alternative splicing of exon 6 and intron 9, respectively. p53 splice variants(More)
Immunosuppression has been often associated with the course of malignant diseases. In the present study, the proliferation of peripheral blood mononuclear cells (PBMCs) in response to mitogenic stimulation with phytohaemagglutinin (PHA) was assessed prospectively in 90 patients with stage I-III breast cancer. Whereas PHA-induced proliferation of PBMCs(More)
BACKGROUND We aimed to evaluate the clinical relevance of p53 and p73 isoforms that modulate the function of p53. METHODS This prospective multicentre study included 154 patients with stage III and IV serous ovarian cancer. A functional yeast-based assay and subsequent sequencing were performed to analyse the p53 mutational status. Expression of p53 and(More)
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