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PURPOSE to describe the population pharmacokinetics of lamotrigine (LTG) in developmentally disabled (DD) patients with epilepsy and (2) to determine if there is an effect of valproate (VPA) concentration on the extent of the pharmacokinetic interaction between VPA and LTG. METHOD a NONMEM population analysis of steady-state LTG serum concentrations was(More)
Spinal cord stimulation is limited by the uncomfortable side effects experienced by the patient as the amplitude of stimulation is increased. These side effects include local segmental paresthesias or motor responses, which are objectively demonstrable as frequency-following muscle contractions, attributable to dorsal root stimulation. The authors present(More)
OBJECTIVE To determine (a) the proportion of women undergoing elective repeat cesarean section without a trial of labour who were eligible for such a trial by the 1986 guidelines of the panel of the National Consensus Conference on Aspects of Cesarean Birth, (b) whether vaginal birth after cesarean section (VBAC) was discussed with these women and (c) the(More)
PROBLEM BEING ADDRESSED The internet has experienced tremendous growth over the past few years and has many resources in the field of family medicine. However, many family physicians remain unaware of how the Internet can be used to enhance their practice and of how to gain access to this powerful tool. OBJECTIVE OF PROGRAM To characterize components of(More)
OBJECTIVE To assess whether physicians were aware of, agreed with, and followed the "1989 Canadian Guidelines for Screening for Chlamydia Trachomatis Infection "as they applied to screening asymptomatic women. DESIGN A survey consisting of direct questions and case scenarios was scored according to the responses given in the guidelines. SETTING Six(More)
iii Acknowledgements I would like to thank Dr. Dalton for helping me to fully examine the sex-related differences of fatigue. I am sincerely grateful for all of the discussion, troubleshooting, teaching, and editing that, in its final form, is displayed through this thesis. It was a privilege to have such an excellent professor to guide me through the(More)
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