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Spinal cord stimulation is limited by the uncomfortable side effects experienced by the patient as the amplitude of stimulation is increased. These side effects include local segmental paresthesias or motor responses, which are objectively demonstrable as frequency-following muscle contractions, attributable to dorsal root stimulation. The authors present(More)
PURPOSE to describe the population pharmacokinetics of lamotrigine (LTG) in developmentally disabled (DD) patients with epilepsy and (2) to determine if there is an effect of valproate (VPA) concentration on the extent of the pharmacokinetic interaction between VPA and LTG. METHOD a NONMEM population analysis of steady-state LTG serum concentrations was(More)
iii Acknowledgements I would like to thank Dr. Dalton for helping me to fully examine the sex-related differences of fatigue. I am sincerely grateful for all of the discussion, troubleshooting, teaching, and editing that, in its final form, is displayed through this thesis. It was a privilege to have such an excellent professor to guide me through the(More)
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