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Activation of cAMP-dependent protein kinase (PKA) can enhance or reduce the function of neuronal GABAA receptors, the major sites of fast synaptic inhibition in the brain. This differential regulation depends on PKA-induced phosphorylation of adjacent conserved sites in the receptor beta subunits. Phosphorylation of beta 3 subunit-containing receptors at(More)
1. The functional role played by the postulated disulphide bridge in gamma-aminobutyric acid type A (GABAA) receptors and its susceptibility to oxidation and reduction were studied using recombinant (murine receptor subunits expressed in human embryonic kidney cells) and rat neuronal GABAA receptors in conjunction with whole-cell and single channel(More)
1. Modulation of GABA(A) receptors by external H(+) was examined in cultured rat sympathetic neurones, and in Xenopus laevis oocytes and human embryonic kidney (HEK) cells expressing recombinant GABA(A) receptors composed of combinations of alpha 1, beta 1, beta 2, gamma 2S and delta subunits. 2. Changing the external pH from 7.4 reduced GABA-activated(More)
gamma-Aminobutyric acid type-A (GABAA) receptors are the major sites of fast synaptic inhibition in the brain. They are presumed to be pentameric heteroligomers assembled from four classes of subunits with multiple members: alpha (1-6), beta (1-3), gamma (1-3) and delta (1). Here, GABAA receptors consisting of alpha 1, beta 1 and gamma 2L subunits,(More)
The competition of magnetic order and superconductivity is a key element in the physics of all unconventional superconductors, for example in high-transition-temperature cuprates, heavy fermions and organic superconductors. Here superconductivity is often found close to a quantum critical point where long-range antiferromagnetic order is gradually(More)
We report upper critical field B c2 (T) data for LaO 0.9 F 0.1 FeAs 1−δ in a wide temperature and field range up to 60 T. The large slope of B c2 ≈-5.4 to-6.6T/K near an improved T c ≈ 28.5 K of the in-plane B c2 (T) contrasts with a flattening starting near 23 K above 30 T we regard as the onset of Pauli-limited behavior (PLB) with B c2 (0) ≈ 63 to 68 T.(More)
We report zero field muon spin relaxation (µSR) measurements on RFeAsO with R = La, Ce, Pr, and Sm. We study the interaction of the FeAs and R (rare earth) electronic systems in the non superconducting magnetically ordered parent compounds of RFeAsO1−xFx superconductors via a detailed comparison of the local hyperfine fields at the muon site with available(More)
We present a study of the magnetic properties of the superparamagnetic ferritin system by employing zero-field (ZF) and longitudinal-field (LF) µ + SR measurements. Two µ + fractions with different depolarisation behaviour are detected, one arising from muons stopped in the organic shell and one from muons stopped in the mineral core. The freezing of the(More)
ImprImé à taxe reduIte-taxe perçue-tassa rIscossa-genova, ItalIe Periodico trim.-Sped. in a.p. art. 2 comma 20/c legge 662/96-Filiale di Genova In caso di mancato recapito rinviare a: In case of delivery failure, please return to: L'Istituto di Economia Internazionale si propone di promuovere gli studi sul-l'economia internazionale. Esso costituisce un(More)
Using muon-spin rotation, we studied the in-plane (lambda_{ab}) and the out of plane (lambda_{c}) magnetic field penetration depth in SrFe_{1.75}Co_{0.25}As_{2} (T_{c} approximately 13.3 K). The penetration depth anisotropy gamma_{lambda} = lambda_{c}/lambda_{ab} increases from gamma_{lambda} approximately 2.1 at T_{c} to 2.7 at 1.6 K. The mean internal(More)