ALINE GOETHALS

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P40 is a cytokine that was originally identified in the mouse as a T cell growth factor, but whose spectrum of potential targets was recently shown to include mast cells as well as megakaryoblastic leukemic cells. Given these multiple activities, it was proposed that the protein be renamed IL-9. The analysis of P40 genomic clones reported here shows that(More)
Helper T cell lines are readily initiated from lymph nodes ofantigen-primed mice by culture in the presence of antigen and irradiated syngeneic APCs (1) . Supernatants collected from these cell lines after stimulation with Con A or phorbol esters contain a variety of factors including IL-2 through IL-6, granulocyte/macrophage colony-stimulating factor(More)
A cDNA encoding the human homolog of mouse T-cell and mast cell growth factor P40 was derived from peripheral blood mononuclear cells (PBMC) stimulated with phytohemagglutinin and phorbol myristate acetate. Sequence analysis of the cDNA predicted a precursor protein of 144 amino acids including a signal peptide of 18 residues, a structure identical with(More)
Recently, we described a murine helper T cell-derived molecule with T cell growth factor activity that is functionally and structurally distinct from IL-2, IL-4, and other known growth factors. This molecule, designated P40, was identified as a glycoprotein capable of supporting antigen-independent growth of certain helper T cell clones. Here, we report the(More)
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