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Insulin-regulated aminopeptidase (IRAP), a transmembrane aminopeptidase, is dynamically retained within the endosomal compartment of fibroblasts. The characteristics of this dynamic retention are rapid internalization from the plasma membrane and slow recycling back to the cell surface. These specialized trafficking kinetics result in <15% of IRAP on the(More)
The SDYQRL motif of the cytoplasmic domain of TGN38 is involved in targeting TGN38 from endosomes to the TGN. To create a system for studying this pathway, we replaced the native transferrin receptor (TR) internalization motif (YTRF) with the SDYQRL TGN-targeting motif. The advantages of using TR as a reporter molecule include the ability to monitor(More)
— The STEM (Science, Technology, Engineering and Math) Teaching Application will provide students with the tools they need to learn different topics in the STEM fields. The application allows users to learn about specific topics they are interested in, or to follow a curriculum for their class. Users can watch short video lessons and tutorials of these(More)
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