Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks
- J. Kluytmans, A. van Belkum, H. Verbrugh
- Medicine, BiologyClinical Microbiology Reviews
- 1 July 1997
Elimination of carriage of S. aureus has been found to reduce the infection rates in surgical patients and those on hemodialysis and CAPD, and those colonized with MRSA.
The role of nasal carriage in Staphylococcus aureus infections.
- H. Wertheim, D. Melles, J. Nouwen
- Medicine, BiologyLancet. Infectious Diseases (Print)
- 1 December 2005
Guidelines for the validation and application of typing methods for use in bacterial epidemiology.
- A. van Belkum, P. Tassios, M. Struelens
- MedicineClinical Microbiology and Infection
- 2007
Newer and older, phenotypic and genotypic methods for typing of all clinically relevant bacterial species are described according to their principles, advantages and disadvantages and Criteria for their evaluation and application and the interpretation of their results are proposed.
Preventing surgical-site infections in nasal carriers of Staphylococcus aureus.
- L. Bode, J. Kluytmans, M. Vos
- MedicineNew England Journal of Medicine
- 7 January 2010
The number of surgical-site S. aureus infections acquired in the hospital can be reduced by rapid screening and decolonizing of nasal carriers of S.aureus on admission, a randomized, double-blind, placebo-controlled, multicenter trial.
Short-Sequence DNA Repeats in Prokaryotic Genomes
- A. van Belkum, S. Scherer, L. van Alphen, H. Verbrugh
- BiologyMicrobiology and Molecular Biology Reviews
- 1 June 1998
Short-sequence DNA repeat (SSR) loci can be identified in all eukaryotic and many prokaryotic genomes and function at various levels of gene expression regulation, and changes in the nature of the individual repeat sequences may result from recombination processes or polymerase inadequacy such as slipped-strand mispairing.
Harmonization of Pulsed-Field Gel Electrophoresis Protocols for Epidemiological Typing of Strains of Methicillin-Resistant Staphylococcus aureus: a Single Approach Developed by Consensus in 10…
- S. Murchan, M. Kaufmann, B. Cookson
- BiologyJournal of Clinical Microbiology
- 1 April 2003
This multinational European Union project has established for the first time a European database of representative epidemic MRSA (EMRSA) strains and has compared them by using a new “harmonized” PFGE protocol developed by a consensus approach that has demonstrated sufficient reproducibility to allow the successful comparison of pulsed-field gels between laboratories and the tracking of strains around the EU.
New Real-Time PCR Assay for Rapid Detection of Methicillin- Resistant Staphylococcus aureus Directly from Specimens Containing a Mixture of Staphylococci
- A. Huletsky, R. Giroux, M. Bergeron
- BiologyJournal of Clinical Microbiology
- 1 May 2004
A real-time multiplex PCR assay which allows the detection of MRSA directly from clinical specimens containing a mixture of staphylococci in <1 h and was not inhibited in the presence of high copy numbers of MSSA, MRCoNS, or MSCoNS.
Moraxella catarrhalis: from Emerging to Established Pathogen
- C. Verduin, C. Hol, A. Fleer, H. van Dijk, A. van Belkum
- Biology, MedicineClinical Microbiology Reviews
- 1 January 2002
Current knowledge of M. catarrhalis is outlined, an organism that has evolved from an emerging to a well-established human pathogen and insights into possible vaccine candidates are provided.
Natural population dynamics and expansion of pathogenic clones of Staphylococcus aureus.
- D. Melles, Raymond F J Gorkink, A. van Belkum
- Biology, MedicineJournal of Clinical Investigation
- 15 December 2004
Evidence is provided that essentially any S. aureus genotype carried by humans can transform into a life-threatening human pathogen but that certain clones are more virulent than others.
Predominance and Emergence of Clones of Hospital-Acquired Methicillin-Resistant Staphylococcus aureus in Malaysia
- E. Ghaznavi-Rad, M. Shamsudin, V. Neela
- Biology, MedicineJournal of Clinical Microbiology
- 20 January 2010
The epidemiology of predominant and sporadic methicillin-resistant Staphylococcus aureus strains in a central teaching and referral hospital in Kuala Lumpur, Malaysia is defined and the predominance of ST-239-SCCmec III/IIIA and the penetration ofST-22 with different virulence gene profiles are revealed.
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