• Publications
  • Influence
Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets.
TLDR
There was dramatic and enhanced sensitivity of NEPC (and MYCN overexpressing PCA) to Aurora kinase inhibitor therapy both in vitro and in vivo, with complete suppression of neuroendocrine marker expression following treatment. Expand
Prognostic value of histologic subtypes in renal cell carcinoma: a multicenter experience.
TLDR
The stratification in three main renal cell carcinoma histologic subtypes as defined by the 1997 UICC-American Joint Committee on Cancer consensus should not be considered a major prognostic variable comparable to TNM stage, Fuhrman grade and ECOG PS. Expand
Positive surgical margin appears to have negligible impact on survival of renal cell carcinomas treated by nephron-sparing surgery.
TLDR
PSM status occurs more frequently in cases in which surgery is imperative and is associated with an increased risk of recurrence, but PSM status does not appear to influence cancer-specific survival. Expand
Clinical utility of the PCA3 urine assay in European men scheduled for repeat biopsy.
TLDR
The PCA3 score was superior to %fPSA for predicting repeat prostate biopsy outcome and may be indicative of clinical stage and significance of pCa. Expand
Prognostic value of renal vein and inferior vena cava involvement in renal cell carcinoma.
TLDR
The level of tumor thrombus in the IVC does not significantly affect long-term overall survival in patients with renal cell carcinoma, and this has to be considered for the next revision of the TNM system. Expand
Safety and efficacy of partial nephrectomy for all T1 tumors based on an international multicenter experience.
TLDR
This large multicenter study suggests that it is safe to expand the indications of partial nephrectomy to include patients with T1N0M0 renal tumors up to 7 cm, however, careful patient selection remains necessary. Expand
Abrogation of De novo Lipogenesis by Stearoyl-CoA Desaturase 1 Inhibition Interferes with Oncogenic Signaling and Blocks Prostate Cancer Progression in Mice
TLDR
The concept of targeting the lipogenic enzyme SCD1 as a new promising therapeutic approach to block oncogenesis and prostate cancer progression is supported for the first time. Expand
Multi-institutional validation of a new renal cancer-specific survival nomogram.
TLDR
The new nomogram is more contemporary, provides predictions that reach further in time and, compared with its alternative, which predicts at 2 and 5 years, generates 3.1% and 2.8% more accurate predictions, respectively. Expand
Use of the University of California Los Angeles integrated staging system to predict survival in renal cell carcinoma: an international multicenter study.
TLDR
The UISS is an accurate predictor of survival for patients with localized RCC applicable to external databases and may be less accurate in this subset of patients due to the heterogeneity of patients and treatments. Expand
Morbidity and clinical outcome of nephron-sparing surgery in relation to tumour size and indication.
TLDR
Excellent cancer control and outcomes can be achieved with NSS in carefully selected patients with tumours >4 cm, and expanding the size indication of elective NSS results in an increased but acceptable morbidity. Expand
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