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The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome.
- P. Bosma, J. Chowdhury, +7 authors R. O. Oude Elferink
- The New England journal of medicine
- 2 November 1995
BACKGROUND People with Gilbert's syndrome have mild, chronic unconjugated hyperbilirubinemia in the absence of liver disease or overt hemolysis. Hepatic glucuronidating activity, essential for… Expand
Instrumental Variables: Application and Limitations
- E. Martens, W. Pestman, A. de Boer, S. Belitser, O. Klungel
- Mathematics, Medicine
- 1 May 2006
To correct for confounding, the method of instrumental variables (IV) has been proposed. Its use in medical literature is still rather limited because of unfamiliarity or inapplicability. By… Expand
Benzodiazepines and the risk of falling leading to femur fractures. Dosage more important than elimination half-life.
- R. Herings, B. Stricker, A. de Boer, Abraham Bakker, F. Sturmans
- Archives of internal medicine
- 11 September 1995
BACKGROUND In the past decade, the use of benzodiazepines has been identified as a major independent risk factor for accidental falls. OBJECTIVE To study the role of dosing, timing, elimination… Expand
Comparison of different pain scoring systems in critically ill patients in a general ICU
BackgroundPain in critically ill patients in the intensive care unit (ICU) is common. However, pain assessment in critically ill patients often is complicated because these patients are unable to… Expand
Influence of correction for within-person variability in blood pressure on the prevalence, awareness, treatment, and control of hypertension.
- O. Klungel, A. de Boer, A. Paes, N. Nagelkerke, J. Seidell, Abraham Bakker
- American journal of hypertension
We assessed the influence of correction for within-person variability (WPV) on the prevalence, awareness, treatment, and control of hypertension. Data were collected from two cross-sectional… Expand
Methods to assess intended effects of drug treatment in observational studies are reviewed.
- O. Klungel, E. Martens, +5 authors A. de Boer
- Journal of clinical epidemiology
- 1 December 2004
BACKGROUND AND OBJECTIVE To review methods that seek to adjust for confounding in observational studies when assessing intended drug effects. METHODS We reviewed the statistical, economical and… Expand
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
Summary Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA… Expand
Validation of pharmacy records in drug exposure assessment.
The validity of drug exposure measurement based on pharmacy records was investigated taking into account completeness of data, drug compliance, and different methods of drug exposure measurement in… Expand
The completeness of medication histories in hospital medical records of patients admitted to general internal medicine wards.
- H. S. Lau, C. Florax, A. Porsius, A. de Boer
- British journal of clinical pharmacology
- 1 June 2000
AIMS Accurate recording of medication histories in hospital medical records (HMR) is important when patients are admitted to the hospital. Lack of registration of drugs can lead to unintended… Expand
Risk of Hip/Femur Fracture After Stroke: A Population-Based Case-Control Study
Background and Purpose— Stroke increases the risk of hip/femur fracture, as seen in several studies, although the time course of this increased risk remains unclear. Therefore, our purpose is to… Expand