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Enabling individualized therapy through nanotechnology.
Individualized medicine is the healthcare strategy that rebukes the idiomatic dogma of 'losing sight of the forest for the trees'. We are entering a new era of healthcare where it is no longer… Expand
A composite smeared finite element for mass transport in capillary systems and biological tissue.
- M. Kojic, M. Milosevic, +6 authors M. Ferrari
- Medicine, Mathematics
- Computer methods in applied mechanics and…
- 1 September 2017
One of the key processes in living organisms is mass transport occurring from blood vessels to tissues for supplying tissues with oxygen, nutrients, drugs, immune cells, and - in the reverse… Expand
Cooperative, nanoparticle-enabled thermal therapy of breast cancer.
Hollow gold nanoshells are more efficient in heat generation triggered by near infrared laser when they are loaded into porous silicon particles, which results in effective cancer-cell killing in… Expand
Capillary-wall collagen as a biophysical marker of nanotherapeutic permeability into the tumor microenvironment.
- K. Yokoi, M. Kojic, M. Milosevic, T. Tanei, M. Ferrari, A. Ziemys
- Cancer research
- 15 August 2014
The capillary wall is the chief barrier to tissue entry of therapeutic nanoparticles, thereby dictating their efficacy. Collagen fibers are an important component of capillary walls, affecting… Expand
Engineering multi-stage nanovectors for controlled degradation and tunable release kinetics.
- J. Martinez, C. Chiappini, +5 authors E. Tasciotti
- Medicine, Materials Science
- 1 November 2013
Nanovectors hold substantial promise in abating the off-target effects of therapeutics by providing a means to selectively accumulate payloads at the target lesion, resulting in an increase in the… Expand
Nanochannel Technology for Constant Delivery of Chemotherapeutics: Beyond Metronomic Administration
- A. Grattoni, H. Shen, +7 authors M. Ferrari
- Medicine, Chemistry
- Pharmaceutical Research
- 1 February 2011
ABSTRACTPurposeThe purpose of this study is to demonstrate the long-term, controlled, zero-order release of low- and high-molecular weight chemotherapeutics through nanochannel membranes by… Expand
Molecular modeling of glucose diffusivity in silica nanochannels.
- A. Ziemys, M. Ferrari, C. Cavasotto
- Materials Science, Medicine
- Journal of nanoscience and nanotechnology
- 1 November 2009
The diffusivity of glucose was studied in confined environment of a 10 nm silica nanochannel to evaluate the influence of the interface on glucose transport at a nano-scale range. Molecular dynamics… Expand
Diffusion transport of nanoparticles at nanochannel boundaries
- T. Mahadevan, M. Milosevic, +5 authors A. Ziemys
- Materials Science
- Journal of Nanoparticle Research
- 8 February 2013
The manipulation of matter at the nanoscale has unleashed a great potential for engineering biomedical drug carriers, but the transport of nanoparticles (NPs) under nanoscale confinement is still… Expand
Improved Multiplex Immunohistochemistry for Immune Microenvironment Evaluation of Mouse Formalin-Fixed, Paraffin-Embedded Tissues
- N. Sorrelle, D. Ganguly, +6 authors R. Brekken
- Biology, Medicine
- The Journal of Immunology
- 1 January 2019
Immune profiling of tissue through multiplex immunohistochemistry is important for the investigation of immune cell dynamics, and it can contribute to disease prognosis and evaluation of treatment… Expand
A robust nanofluidic membrane with tunable zero-order release for implantable dose specific drug delivery.
This manuscript demonstrates a mechanically robust implantable nanofluidic membrane capable of tunable long-term zero-order release of therapeutic agents in ranges relevant for clinical applications.… Expand