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Isoform-specific Inhibition of TRPC4 Channel by Phosphatidylinositol 4,5-Bisphosphate*
- K. Otsuguro, J. Tang, +7 authors A. Zholos
- Biology, Medicine
- Journal of Biological Chemistry
- 11 April 2008
Full-length transient receptor potential (TRP) cation channel TRPC4α and shorter TRPC4β lacking 84 amino acids in the cytosolic C terminus are expressed in smooth muscle and endothelial cells where… Expand
Excitation-contraction coupling in gastrointestinal and other smooth muscles.
The main contributors to increases in [Ca2+]i and tension are the entry of Ca2+ through voltage-dependent channels opened by depolarization or during action potential (AP) or slow-wave discharge, and… Expand
Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo.
- V. V. Tsvilovskyy, A. Zholos, +6 authors V. Flockerzi
- Biology, Medicine
- 1 October 2009
BACKGROUND & AIMS Downstream effects of muscarinic receptor stimulation in intestinal smooth muscle include contraction and intestinal transit. We thought to determine whether classic transient… Expand
Transient receptor potential melastatin 8 channel involvement in the regulation of vascular tone.
- C. Johnson, D. Melanaphy, Andrew Purse, Susan A Stokesberry, P. Dickson, A. Zholos
- Medicine, Biology
- American journal of physiology. Heart and…
- 10 April 2009
The transient receptor potential melastatin 8 (TRPM8) channel has been characterized as a cold and menthol receptor expressed in a subpopulation of sensory neurons but was recently identified in… Expand
Muscarinic receptor subtypes controlling the cationic current in guinea‐pig ileal smooth muscle
1 The effects of muscarinic antagonists on cationic current evoked by activating muscarinic receptors with the stable agonist carbachol were studied by use of patch‐clamp recording techniques in… Expand
G-protein control of voltage dependence as well as gating of muscarinic metabotropic channels in guinea-pig ileum.
1. Voltage-dependent properties of muscarinic receptor cationic current activated by carbachol in single smooth muscle cells have been studied using patch-clamp recording techniques. Cells were… Expand
Activation of M2 muscarinic receptors in guinea-pig ileum opens cationic channels modulated by M3 muscarinic receptors.
In longitudinal muscle of guinea-pig ileum, activation of muscarinic receptors causes contraction antagonised by M3 receptor subtype antagonists despite a preponderance of M2 receptor subtype binding… Expand
Potassium channels of myenteric neurons in guinea-pig small intestine
Patch-clamp recording was used to study rectifying K+ currents in myenteric neurons in short-term culture. In conditions that suppressed Ca2+ -activated K+ current, three kinds of voltage-activated… Expand
Modulation of calcium currents by G‐proteins and adenosine receptors in myenteric neurones cultured from adult guinea‐pig small intestine
1 Whole‐cell patch clamp methods were used to analyse voltage‐dependent calcium currents in cultured myenteric neurones enzymatically isolated from adult guinea‐pig small intestine 2 Activation of… Expand
Increased expression of bronchial epithelial transient receptor potential vanilloid 1 channels in patients with severe asthma.
- L. Mcgarvey, C. A. Butler, +14 authors L. Heaney
- The Journal of allergy and clinical immunology
- 1 March 2014
BACKGROUND The airway epithelium is exposed to a range of physical and chemical irritants in the environment that are known to trigger asthma. Transient receptor potential (TRP) cation channels play… Expand