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Isoform-specific Inhibition of TRPC4 Channel by Phosphatidylinositol 4,5-Bisphosphate*
Full-length transient receptor potential (TRP) cation channel TRPC4α and shorter TRPC4β lacking 84 amino acids in the cytosolic C terminus are expressed in smooth muscle and endothelial cells whereExpand
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Excitation-contraction coupling in gastrointestinal and other smooth muscles.
The main contributors to increases in [Ca2+]i and tension are the entry of Ca2+ through voltage-dependent channels opened by depolarization or during action potential (AP) or slow-wave discharge, andExpand
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Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo.
BACKGROUND & AIMS Downstream effects of muscarinic receptor stimulation in intestinal smooth muscle include contraction and intestinal transit. We thought to determine whether classic transientExpand
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Transient receptor potential melastatin 8 channel involvement in the regulation of vascular tone.
The transient receptor potential melastatin 8 (TRPM8) channel has been characterized as a cold and menthol receptor expressed in a subpopulation of sensory neurons but was recently identified inExpand
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Muscarinic receptor subtypes controlling the cationic current in guinea‐pig ileal smooth muscle
1 The effects of muscarinic antagonists on cationic current evoked by activating muscarinic receptors with the stable agonist carbachol were studied by use of patch‐clamp recording techniques inExpand
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G-protein control of voltage dependence as well as gating of muscarinic metabotropic channels in guinea-pig ileum.
1. Voltage-dependent properties of muscarinic receptor cationic current activated by carbachol in single smooth muscle cells have been studied using patch-clamp recording techniques. Cells wereExpand
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Activation of M2 muscarinic receptors in guinea-pig ileum opens cationic channels modulated by M3 muscarinic receptors.
In longitudinal muscle of guinea-pig ileum, activation of muscarinic receptors causes contraction antagonised by M3 receptor subtype antagonists despite a preponderance of M2 receptor subtype bindingExpand
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Potassium channels of myenteric neurons in guinea-pig small intestine
Patch-clamp recording was used to study rectifying K+ currents in myenteric neurons in short-term culture. In conditions that suppressed Ca2+ -activated K+ current, three kinds of voltage-activatedExpand
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Modulation of calcium currents by G‐proteins and adenosine receptors in myenteric neurones cultured from adult guinea‐pig small intestine
1 Whole‐cell patch clamp methods were used to analyse voltage‐dependent calcium currents in cultured myenteric neurones enzymatically isolated from adult guinea‐pig small intestine 2 Activation ofExpand
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Increased expression of bronchial epithelial transient receptor potential vanilloid 1 channels in patients with severe asthma.
BACKGROUND The airway epithelium is exposed to a range of physical and chemical irritants in the environment that are known to trigger asthma. Transient receptor potential (TRP) cation channels playExpand
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