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Doxorubicin induces atypical NF-κB activation through c-Abl kinase activity in breast cancer cells
PurposeNF-κB transcription factor has been associated with cancer development and chemoresistance. We studied the signaling pathway activated by doxorubicin (DOX) leading to NF-κB activation inExpand
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Vascular permeability changes involved in tumor metastasis.
Cancer cell extravasation resembles the leukocyte recruitment during inflammation. Evidence suggests that cancer cells need to weaken the interendothelial junctions in order to cross the endothelialExpand
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Reversal of multidrug resistance by morning glory resin glycosides in human breast cancer cells.
Reversal of multidrug resistance (MDR) by thirty resin glycosides from the morning glory family (Convolvulaceae) was evaluated in vinblastine-resistant human breast carcinoma cells (MCF-7/Vin). TheExpand
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Placental blood leukocytes are functional and phenotypically different than peripheral leukocytes during human labor.
Rupture of the fetal membranes during human labor is associated with an inflammatory process localized to the maternal-fetal interface. There is evidence that specific leukocytes subsets areExpand
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Casiopeina II-gly and bromo-pyruvate inhibition of tumor hexokinase, glycolysis, and oxidative phosphorylation
The copper-based drug Casiopeina II-gly (CasII-gly) shows potent antineoplastic effect and diminishes mitochondrial metabolism on several human and rodent malignant tumors. To elucidate whetherExpand
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SOX2 as a New Regulator of HPV16 Transcription
Persistent infections with high-risk human papillomavirus (HPV) constitute the main risk factor for cervical cancer development. HPV16 is the most frequent type associated to squamous cell carcinomasExpand
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Characterization of a naturally occurring new version of the cholesterol ester transfer protein (CETP) from small intestine
The cholesterol ester transfer protein (CETP) is found in plasma mediating the transfer of cholesterol esters and triacylglycerides between lipoproteins. The last 26 amino acids of its carboxy-endExpand
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HSP-72 Accelerated Expression in Mononuclear Cells Induced In Vivo by Acetyl Salicylic Acid Can Be Reproduced In Vitro when Combined with H2O2
Background Among NSAIDs acetyl salicylic acid remains as a valuable tool because of the variety of benefic prophylactic and therapeutic effects. Nevertheless, the molecular bases for these responsesExpand
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Glycine suppresses TNF-α-induced activation of NF-κB in differentiated 3T3-L1 adipocytes.
Glycine strongly reduces the serum levels of pro-inflammatory cytokines and increases the levels of anti-inflammatory cytokines. Recently, glycine has been shown to decrease the expression andExpand
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NF-kappaB dependent activation of human endothelial cells treated with soluble products derived from human lymphomas.
Nuclear factor of the Immunoglobulin Kappa chain of B cells (NF-kappaB) activation is an early event during cytokine-mediated endothelial activation related to increased adhesion of leucocytes. WeExpand
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