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Big Effects from Small Changes: Possible Ways to Explore Nature's Chemical Diversity
The systematic alteration of easily accessible cultivation parameters in order to increase the number of secondary metabolites available from one microbial source is investigated and the OSMAC approach seems to be a useful tool to detect those metabolites that are postulated to be the final products of an amazing number of typical secondary metabolites gene clusters identified in several microorganisms.
Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases.
The structure-activity study showed that in general the concanamycins, 18-membered macrolides, are better and more specific inhibitors than the bafilomycins of this class of membrane-bound ATPases.
Concanamycin A, the Specific Inhibitor of V-ATPases, Binds to the Vo Subunit c*
Binding of J-concanolide A to subunit c was prevented in a concentration-dependent manner by concanamycin A, indicating that labeling was specific, and binding was also prevented by the plecomacrolides bafilomycin A1 and B1, respectively.
Archazolid and apicularen: Novel specific V-ATPase inhibitors
The myxobacterial antibiotics archazolid and apicularen are highly efficient and specific novel inhibitors of V-ATPases.
Chinikomycins A and B: isolation, structure elucidation, and biological activity of novel antibiotics from a marine Streptomyces sp. isolate M045.
Chinikomycins A and B are chlorine-containing aromatized manumycin derivatives of the type 64-pABA-2 with an unusual para orientation of the side chains that exhibited antitumor activity against different human cancer cell lines, but were inactive in antiviral, antimicrobial, and phytotoxicity tests.
Bagremycin A and B, novel antibiotics from streptomyces sp. Tü 4128.
Two novel secondary metabolites, bagremycin A (2) and B (3), were detected in the culture filtrate of Streptomyces sp. Tü 4128 by HPLC-diode-array screening. They are phenol esters of
Purification and characterization of a pyranose oxidase from the basidiomycete Peniophora gigantea and chemical analyses of its reaction products.
The pyranose oxidase was shown to be an extremely stable glycoprotein with an isoelectric point of pH 5.3 and contains covalently bound FAD with an estimated stoichiometry of 3.6 molecules FAD/molecule enzyme.
Screening for biologically active metabolites with endosymbiotic bacilli isolated from arthropods.
Endosymbiotic bacteria from the genus Bacillus were isolated from different compartments of the gut of various members of insects and millipedes regarding their production of bioactive metabolites, which were isolated and determined in structure.