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Big Effects from Small Changes: Possible Ways to Explore Nature's Chemical Diversity
Fungi or bacteria that produce secondary metabolites often have the potential to bring up various compounds from a single strain. The molecular basis for this well‐known observation was confirmed inExpand
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Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases.
Various ATPases have been tested for their sensitivity to naturally occurring unusual macrolides and their chemically modified derivatives, which are structurally related to bafilomycin A1 (1), theExpand
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Concanamycin A, the Specific Inhibitor of V-ATPases, Binds to the Vo Subunit c*
Vacuolar-type ATPase (V-ATPase) purified from the midgut of the tobacco hornworm Manduca sexta is inhibited 50% by 10 nm of the plecomacrolide concanamycin A, the specific inhibitor of V-ATPases. ToExpand
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Archazolid and apicularen: Novel specific V-ATPase inhibitors
BackgroundV-ATPases constitute a ubiquitous family of heteromultimeric, proton translocating proteins. According to their localization in a multitude of eukaryotic membranes, they energize manyExpand
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Chinikomycins A and B: isolation, structure elucidation, and biological activity of novel antibiotics from a marine Streptomyces sp. isolate M045.
In our screening of marine Streptomycetes for bioactive principles, two novel antitumor antibiotics designated as chinikomycins A (2a) and B (2b) were isolated together with manumycin A (1), andExpand
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Purification and characterization of a pyranose oxidase from the basidiomycete Peniophora gigantea and chemical analyses of its reaction products.
A pyranose oxidase was isolated from mycelium extracts of the basidiomycete Peniophora gigantea. This enzyme was purified 104-fold to apparent homogeneity with a yield of about 75% by steps involvingExpand
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Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tü 6040. I. Taxonomy, fermentation, isolation and biological activities.
Two novel angucyclinone-type antibiotics, simocyclinones D4 and D8, were detected in the mycelium extract of Streptomyces antibioticus Tü 6040 by HPLC-diode-array andExpand
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Screening for biologically active metabolites with endosymbiotic bacilli isolated from arthropods.
Endosymbiotic bacteria from the genus Bacillus were isolated from different compartments of the gut of various members of insects (Hexapoda) and millipedes (Diplopoda). They were grown in submergedExpand
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Cladospirones B to I from Sphaeropsidales sp. F‐24′707 by Variation of Culture Conditions
Variation of the culture conditions − static surface cultures in particular − of the fungus Sphaeropsidales sp. (strain F-24′707), which produces cladospirone bisepoxide (1), led to the isolation ofExpand
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