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Structural Basis for the Substrate Specificity of Tobacco Etch Virus Protease*
Because of its stringent sequence specificity, the 3C-type protease from tobacco etch virus (TEV) is frequently used to remove affinity tags from recombinant proteins. It is unclear, however, exactlyExpand
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The structural basis for spectral variations in green fluorescent protein
Based on structures of five mutants of green fluorescent protein (GFP), we describe two conformational variants with differing charge distribution that explain the published absorption andExpand
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Crystal structure of plant aspartic proteinase prophytepsin: inactivation and vacuolar targeting
We determined at 2.3 Å resolution the crystal structure of prophytepsin, a zymogen of a barley vacuolar aspartic proteinase. In addition to the classical pepsin‐like bilobal main body of phytepsin,Expand
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Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma.
BACKGROUND Interleukin (IL)-10 is a cytokine that inhibits production of other regulatory factors, including interferon gamma (IFN-gamma) and IL-2. A dimer of IL-10 is present in solution and isExpand
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Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase
Porphobilinogen synthase (PBGS) catalyzes the first common step in the biosynthesis of tetrapyrroles (such as heme and chlorophyll). Although the predominant oligomeric form of this enzyme, asExpand
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Structural features of the interleukin-10 family of cytokines.
  • A. Zdanov
  • Biology, Medicine
  • Current pharmaceutical design
  • 30 November 2004
The interleukin-10 (IL-10) family of cytokines includes IL-10, a number of its viral gene homologs, and eight recently discovered cellular cytokines (IL-19, IL-20, IL-22, IL-24, IL-26, IFN-lambda1,Expand
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Structural analysis of cytokines comprising the IL-10 family.
  • A. Zdanov
  • Biology, Medicine
  • Cytokine & growth factor reviews
  • 1 October 2010
Interleukin-10 (IL-10) family of cytokines includes a number of its viral homologs and eight cellular cytokines (IL-19, IL-20, IL-22, IL-24, IL-26, IL-28A, IL-28B, and IL-29). The latter threeExpand
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Structure and mechanism of activity of the cyclic phosphodiesterase of Appr>p, a product of the tRNA splicing reaction
The crystal structure of the cyclic phosphodiesterase (CPDase) from Arabidopsis thaliana, an enzyme involved in the tRNA splicing pathway, was determined at 2.5 Å resolution. CPDase hydrolyzesExpand
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Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20.
The soluble extracellular domains of human interleukin-20 (IL-20) receptors I and II (sIL-20R1 and sIL20R2), along with their ligands IL-19 and IL-20, were expressed in Drosophila S2 cells andExpand
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Crystal Structure of Human Interferon-λ1 in Complex with Its High-Affinity Receptor Interferon-λR1
Abstract Interferon (IFN)-λ1 [also known as interleukin (IL)-29] belongs to the recently discovered group of type III IFNs. All type III IFNs initiate signaling processes through formation ofExpand
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