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Chiral BINOL-derived phosphoric acids: privileged Brønsted acid organocatalysts for C-C bond formation reactions.
The recent advances have been reviewed in this article with a focus being placed on hydrocyanations, aldol-type, Mannich, Friedel-Crafts, aza-ene- type, Diels-Alder, as well as cascade and multi-component reactions. Expand
Developments in Chiral Binaphthyl-Derived Bronsted/Lewis Acids and Hydrogen-Bond-Donor Organocatalysis
In recent years, binaphthyl compounds have found frequent applications in the design of various asymmetric organocatalysts, because binaphthyl structures are an attractive platform for organocatalystExpand
Highly enantioselective organocatalytic formation of a quaternary carbon center via chiral Brønsted acid catalyzed self-coupling of enamides.
The enantioselective BINOL-phosphate catalyzed formation of a quaternary carbon center, bearing a N-atom has been achieved through the self-coupling reaction of enamides and their application for the synthesis of versatile synthetic building blocks-beta-aminoketones-has been demonstrated. Expand
Spontaneous Mirror Symmetry Breaking in the Aldol Reaction and its Potential Relevance in Prebiotic Chemistry
It is shown that reactant precipitation observed in the earlier reported experiments does not affect the asymmetric autocatalysis in the aldol reaction the authors studied and the phenomenon of spontaneous mirror symmetry breaking in such organocatalytic homogenous systems qualitatively is explained. Expand
Asymmetric hydrocyanation of hydrazones catalyzed by in situ formed O-silylated BINOL-phosphate: a convenient access to versatile alpha-hydrazino acids.
A first organocatalytic enantioselective route was developed for the conversion of readily prepared and air stable aliphatic hydrazones to synthetically valuable alpha-hydrazinonitriles. ThisExpand
Combining in situ Generated Chiral Silicon Lewis Acid and Chiral Brønsted Acid Catalysts for [3+2] Cycloadditions: Cooperative Catalysis as a Convenient Enantioselective Route to Pyrazolidines
A facile enantioselective synthesis of chiral pyrazolidines via a [3+2] cycloaddition reaction, involving a BINOL-derived phosphoric acid and an in situ generated BINOL phosphate-derived siliconExpand
Silicon Lewis Acid Catalyzed [3+2] Cycloaddition Reactions of Hydrazones/Cyclopentadiene: Mild Access to Pyrazolidine Derivatives
A first and fairly mild metal-free catalytic route was developed for the [3+2] cycloadditions of different N-acylhydrazones to cyclopentadiene, providing the synthetically andbiologically importantExpand
Towards a Catalytic AsymmetricVersion of the [3+2] Cycloaddition between Hydrazonesand Cyclopentadiene
A novel and easily accessible metal-free catalytic system, an in situ generated BINOL-phosphate-derived silicon Lewis acid, has been described for the [3+2] cycloaddition of N-benzoyl-hydrazone toExpand
Synthesis of BACE Inhibitor LY2886721. Part I. An Asymmetric Nitrone Cycloaddition Strategy
A scalable, asymmetric synthesis of (3aS,6aS)-6a-(5-bromo-2-fluorophenyl)-1-((R)-1-phenylpropyl)tetrahydro-1H,3H-furo[3,4-c]isoxazole, a key intermediate in the synthesis of LY2886721, is reported.Expand