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Systemic miRNA-7 delivery inhibits tumor angiogenesis and growth in murine xenograft glioblastoma
TLDR
This study provides a comprehensive validation of miR-7 as novel anti-angiogenic therapeutic miRNA that can be systemically delivered to both EC and tumor cells and offers promise for miR -7 as Novel anti-tumor therapeutic. Expand
Preparation and In Vitro Evaluation of a Pegylated Nano-Liposomal Formulation Containing Docetaxel
An improved pegylated liposomal formulation of docetaxel has been developed with the purpose of improving the docetaxel solubility without any need to use tween80 that is responsible forExpand
An in vitro assay based on surface plasmon resonance to predict the in vivo circulation kinetics of liposomes.
TLDR
An in vitro assay measuring interactions of liposomes with proteins to predict their blood clearance in vivo is introduced, which reduces the number of animals required for pharmacokinetic investigations of new formulations and shows moderate to strong positive correlation with the clearance of the liposome type. Expand
Trends in polymeric delivery of nucleic acids to tumors.
TLDR
Various barriers which polymeric DNA or siRNA nanoparticles encounter upon systemic administration are discussed with an aim to assist in designing more relevant in vitro assays. Expand
Anginex lipoplexes for delivery of anti-angiogenic siRNA.
TLDR
A galectin-1 targeted anginex-coupled lipoplex (Angiplex) containing siRNA against the gene of VEGFR-2 as an angiostatic therapeutic is characterized and gene silencing efficiency of Angiplex was shown to be 61%. Expand
Thermosensitive Drug Permeation through Liquid Crystal-Embedded Cellulose Nitrate Membranes.
TLDR
It was found that the drug permeation through the membrane could be modulated by changing the temperature below and above the T(n-i) of liquid crystals, which was more temperature-dependent than metronidazole, the hydrophobic drug with higher molecular weight. Expand
Hemocompatibility Assessment of two siRNA Nanocarrier Formulations
TLDR
Results indicated that pHPMA-MPPM polyplex triggered high platelet activation and aggregation although it did not stimulate coagulation substantially, which may help the selection of suitable carriers for systemic delivery of siRNA in early preclinical investigations and reduce the use of laboratory animals significantly. Expand
In vitro Characterization of a Lipidic Delivery System for Anti-angiogenic siRNA
SUMMARY In this study, Anginex lipoplexes (AxL) were developed for intracellular delivery of non-coding RNA (ncRNA) to endothelial cells of tumor vasculature. Physicochemical characteristics,Expand
Metal organic framework nanoparticles loaded- PVDF/chitosan nanofibrous ultrafiltration membranes for the removal of BSA protein and Cr(VI) ions
Abstract The UiO-66 NH2 and ZIF-8 metal organic framework nanoparticles (NMOFs) were incorporated into the polyvinylidene fluoride (PVDF) nanofibrous membrane. Then, the chitosan nanofibers wereExpand
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