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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
TLDR
This study has demonstrated that careful use of a shared control group represents a safe and effective approach to GWA analyses of multiple disease phenotypes; generated a genome-wide genotype database for future studies of common diseases in the British population; and shown that, provided individuals with non-European ancestry are excluded, the extent of population stratification in theBritish population is generally modest. Expand
A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder.
TLDR
Euthymic bipolar patients demonstrate relatively marked impairment in aspects of executive function and verbal memory, and it is not yet clear whether these are two discrete areas of impairment or are related to one another. Expand
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
TLDR
The results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder and found further support for the previously reported CACNA1C. Expand
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
TLDR
Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders. Expand
Neurocognitive impairment in drug-free patients with major depressive disorder
TLDR
Pronounced neurocognitive impairment was found in this sample of young adult out-patients with MDD, and could therefore provide an objective marker of brain dysfunction in depression. Expand
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
TLDR
These findings, enabled in part by increased statistical power resulting from the expansion of the control reference group to include individuals from the other disease groups, highlight notable new possibilities for autoimmune regulation and suggest that IL23R may be a common susceptibility factor for the major 'seronegative' diseases. Expand
Neurocognitive impairment in euthymic patients with bipolar affective disorder
TLDR
Neurocognitive impairment persists in patients whose bipolar disorder is in remission and may represent a trait abnormality and be a marker of underlying neurobiological dysfunction. Expand
Tryptophan depletion in normal volunteers produces selective impairments in learning and memory
TLDR
Computerized tests of memory, learning and executive function revealed selective and non-sedative impairments on cognitive performance following the active drink, supporting instead a specific role for the serotonergic system in the processes of memory and learning not directly implicated in frontal lobe function. Expand
Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar
The Canadian Network for Mood and Anxiety Treatments (CANMAT) published guidelines for the management of bipolar disorder in 2005, with a 2007 update. This second update, in conjunction with theExpand
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
TLDR
A large, direct genome-wide study of association between CNVs and eight common human diseases concludes that common CNVs that can be typed on existing platforms are unlikely to contribute greatly to the genetic basis ofcommon human diseases. Expand
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