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Activation of distinct cAMP-dependent and cGMP-dependent pathways by nitric oxide in cardiac myocytes.
It is concluded that NO can regulate both AC and GC in cardiac myocytes, and high levels of NO induce large increases in cGMP and a negative inotropic effect mediated by a PKG-dependent reduction in myofilament responsiveness to Ca2+. Expand
Constitutive Phosphodiesterase Activity Restricts Spontaneous Beating Rate of Cardiac Pacemaker Cells by Suppressing Local Ca2+ Releases
Spontaneous beating of rabbit sinoatrial node cells (SANCs) is controlled by cAMP-mediated, protein kinase A–dependent local subsarcolemmal ryanodine receptor Ca2+ releases (LCRs). LCRs activated anExpand
Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca(2+) cycling and I(KACh).
Numerical model simulations demonstrated that Ca(2+) cycling is integrated into the cholinergic modulation of BRR via LCR-induced activation of NCX current, providing theoretical support for the experimental findings. Expand
Ca2+-stimulated Basal Adenylyl Cyclase Activity Localization in Membrane Lipid Microdomains of Cardiac Sinoatrial Nodal Pacemaker Cells*
It is shown by quantitative reverse transcriptase PCR that SANC express Ca2+-activated AC isoforms 1 and 8, in addition to AC type 2, 5, and 6 transcripts, and that ACs localize to membrane lipid microdomains. Expand
Rapamycin inhibits alpha 1-adrenergic receptor-stimulated cardiac myocyte hypertrophy but not activation of hypertrophy-associated genes. Evidence for involvement of p70 S6 kinase.
It is demonstrated that p70S6K is activated by the hypertrophic agent PE and that a PI3-K or PI2-K-like activity is required for p70s6K activation and myocyte hypertrophy. Expand
Resveratrol and curcumin enhance pancreatic β-cell function by inhibiting phosphodiesterase activity
A novel role for natural-occurring polyphenols as PDE inhibitors that enhance pancreatic β-cell function is demonstrated. Expand
Mechanism of uptake of technetium-tetrofosmin. II: Uptake into isolated adult rat heart mitochondria
It was concluded that the accumulation of 99mTc-labeled tetrofosmin by the mitochondria is related to their ability to transduce metabolic energy into electronegative membrane potential. Expand
Aging, cardiac proenkephalin mRNA and enkephalin peptides in the Fisher 344 rat.
The age-associated patterns in both PENK mRNA, ME and LE suggest that physiological, maturational or behavioral events between 3 and 7 months of age initiate the up-regulation and subsequent expansion of cardiac enkephalinergic systems. Expand
Dimethylthiourea, an oxygen radical scavenger, protects isolated cardiac myocytes from hypoxic injury by inhibition of Na(+)-Ca2+ exchange and not by its antioxidant effects.
The protective effect of DMTU was not observed when it was added at reoxygenation, suggesting that this agent has an important effect during the hypoxic period when intracellular Ca2+ is known to rise, most likely because of the reversal of Na(+)-Ca2+ exchange. Expand
Bépridil a new effector of oxidative phosphorylations.
Bépridil action on oxidative phosphorylations depends on the nature of the oxidized substrate. Thus it seemed to act as an uncoupler on the FAD-linked substrates as we have shown with succinate. ButExpand