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Activation of AML1‐mediated transcription by MOZ and inhibition by the MOZ–CBP fusion protein
The AML1–CBFβ transcription factor complex is the most frequent target of specific chromosome translocations in human leukemia. The MOZ gene, which encodes a histone acetyltransferase (HAT), is alsoExpand
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GlcNAcylation of histone H2B facilitates its monoubiquitination
Chromatin reorganization is governed by multiple post-translational modifications of chromosomal proteins and DNA. These histone modifications are reversible, dynamic events that can regulateExpand
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Interaction and functional cooperation of the leukemia‐associated factors AML1 and p300 in myeloid cell differentiation
The AML1 transcription factor and the transcriptional coactivators p300 and CBP are the targets of chromosome translocations associated with acute myeloid leukemia and myelodysplastic syndrome. InExpand
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The androgen receptor in health and disease.
Androgens play pivotal roles in the regulation of male development and physiological processes, particularly in the male reproductive system. Most biological effects of androgens are mediated by theExpand
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Transrepressive Function of TLX Requires the Histone Demethylase LSD1
ABSTRACT TLX is an orphan nuclear receptor (also called NR2E1) that regulates the expression of target genes by functioning as a constitutive transrepressor. The physiological significance of TLX inExpand
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TET3–OGT interaction increases the stability and the presence of OGT in chromatin
Gene expression is controlled by alterations in the epigenome, including DNA methylation and histone modification. Recently, it was reported that 5‐methylcytosine (5mC) is converted toExpand
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Nuclear receptor coregulators merge transcriptional coregulation with epigenetic regulation.
Members of the nuclear steroid/thyroid hormone receptor (NR) gene superfamily are DNA-binding transcription factors that regulate target genes in a spatiotemporal manner, depending on the promoterExpand
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Clinical and genetic investigation of 17 Japanese patients with hyperekplexia
The aim of the study was to determine clinical and genetic characteristics of Japanese patients with hyperekplexia.
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Retracted: A cell cycle‐dependent co‐repressor mediates photoreceptor cell‐specific nuclear receptor function
Photoreceptor cell‐specific nuclear receptor (PNR) (NR2E3) acts as a sequence‐specific repressor that controls neuronal differentiation in the developing retina. We identified a novel PNRExpand
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Identification of Myelin Transcription Factor 1 (MyT1) as a Subunit of the Neural Cell Type-specific Lysine-specific Demethylase 1 (LSD1) Complex*
Background: The composition of tissue-specific complexes that modify histone is largely unknown. Results: We identified myelin transcription factor 1 (MyT1) as a lysine-specific demethylase 1 (LSD1)Expand
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