A. Yokomizo

Publications20
h-index9
Citations312
Highly Influential Citations4
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Increased expression of DNA topoisomerase I gene and collateral sensitivity to camptothecin in human cisplatin-resistant bladder cancer cells.
We established three cis-diamminedichloroplatinum(II) (cisplatin)-resistant cell lines, T24/DDP5, T24/DDP7, and T24/DDP10, by the stepwise exposure of T24 human bladder cancer cells to increasing…
Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: a novel, potent and…
Hand assisted laparoscopic radical nephrectomy for renal carcinoma using a new abdominal wall sealing device.
Discovery of atrop fixed alkoxy-aminobenzhydrol derivatives: novel, highly potent and orally efficacious squalene synthase inhibitors.
Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors.
Enhanced expression of gamma-glutamylcysteine synthetase and glutathione S-transferase genes in cisplatin-resistant bladder cancer cells with multidrug resistance phenotype.
Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: exploration of 5-6 fused rings as alternative S1 moieties.
Impact of reporting rules of biopsy Gleason score for prostate cancer
TLDR
Clinicians should be aware that the reporting rules, especially the highest-core scoring, contribute to a significant upward shift of the biopsy Gleason score and risk classification.
Synthesis of phenoxyacetic acid derivatives as highly potent antagonists of gastrin/cholecystokinin-B receptors. II.
TLDR
DA-3934 and its methyl ester derivative inhibited pentagastrin-induced gastric acid secretion in rats in a dose-dependent manner and exhibited high affinity for gastrin/CCK-B receptors and high selectivity over CCK-A receptors.
Accumulation of intracellular platinum is correlated with intrinsic cisplatin resistance in human bladder cancer cell lines.
TLDR
Investigation of the mechanism of intrinsic resistance to cisplatin in human transitional cell cancer using 7 human bladder cancer cell lines suggests that intracellular cisPlatin may contribute to intrinsic cis platin resistance and may therefore be a useful biomarker to predict cisplatoon sensitivity in human untreated TCC.
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