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Targeting Insulin and Insulin-Like Growth Factor Pathways in Epithelial Ovarian Cancer
Ovarian cancer is the most lethal of all gynecological malignancies, due in part to the diagnosis at an advanced stage caused by the lack of specific signs and symptoms and the absence of reliable… Expand
Anti-diabetic doses of metformin decrease proliferation markers in tumors of patients with endometrial cancer.
BACKGROUND Metformin has been associated with reduced cancer risk. The mechanisms underlying this cancer protective effect remain unknown. METHODS "Window of opportunity" study of metformin in… Expand
Induction of apoptosis by metformin in epithelial ovarian cancer: involvement of the Bcl-2 family proteins.
- A. Yasmeen, M. Beauchamp, E. Piura, E. Segal, M. Pollak, W. Gotlieb
- Gynecologic oncology
- 1 June 2011
OBJECTIVE The aims of the study were to evaluate the ability of metformin to induce apoptosis in epithelial ovarian cancer cell lines and to identify the pathways involved in this effect. METHODS… Expand
High-risk human papillomavirus infections in breast cancer in Syrian women and their association with Id-1 expression: a tissue microarray study
- N. Akil, A. Yasmeen, A. Kassab, L. Ghabreau, A. Darnel, A. Al Moustafa
- British Journal of Cancer
- 22 July 2008
High-risk human papillomaviruses (HPVs) could be important risk factors for breast carcinogenesis and metastasis. Based on this hypothesis, we recently studied the effect of E6/E7 onco-proteins of… Expand
Significant toxic role for single-walled carbon nanotubes during normal embryogenesis.
- D. Roman, A. Yasmeen, Matei Mireuta, I. Stiharu, Ala-Eddin Al Moustafa
- Medicine, Biology
- Nanomedicine : nanotechnology, biology, and…
- 1 October 2013
UNLABELLED In order to investigate the effect of SWCNTs in the embryo, we examined the outcome of SWCNTs in avian embryo at an early stage of development. We found that SWCNTs-treatment inhibits the… Expand
Metformin Increases E-cadherin in Tumors of Diabetic Patients With Endometrial Cancer and Suppresses Epithelial-Mesenchymal Transition in Endometrial Cancer Cell Lines
- I. Laskov, Paul Abou-Nader, +4 authors W. Gotlieb
- International Journal of Gynecologic Cancer
- 17 April 2016
Purpose Epithelial-mesenchymal transition (EMT) is a critical process for cancer metastasis and recurrence. Metformin, an effective oral antidiabetic drug, has been associated with decreased cancer… Expand
High-risk human papillomavirus infections in colorectal cancer in the Syrian population and their association with Fascin, Id-1 and P-cadherin expressions: A tissue microarray study
Background: High-risk human papillomaviruses (HPVs) can be regarded as important risk factors for colorectal carcinogenesis and metastasis. Alternatively, earlier studies have reported that Fascin,… Expand
Relevance of the OCT1 transporter to the antineoplastic effect of biguanides.
- E. Segal, A. Yasmeen, M. Beauchamp, J. Rosenblatt, M. Pollak, W. Gotlieb
- Biology, Medicine
- Biochemical and biophysical research…
- 4 November 2011
Epidemiologic and laboratory data suggesting that metformin has antineoplastic activity have led to ongoing clinical trials. However, pharmacokinetic issues that may influence metformin activity have… Expand
Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors
BackgroundPhosphatase and Tensin homolog (PTEN) is a tumor suppressor gene. Loss of its function is the most frequent genetic alteration in endometrioid endometrial cancers (70–80%) and high grade… Expand
Clinical outcome of neoadjuvant chemotherapy for advanced ovarian cancer.
OBJECTIVE To evaluate clinical outcome in patients selected to receive neoadjuvant chemotherapy (NACT) compared to primary debulking surgery (PDS). METHODS Retrospective study including all… Expand