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Medicinal Plants Database and Three Dimensional Structure of the Chemical Compounds from Medicinal Plants in Indonesia
During this era of new drug designing, medicinal plants had become a very interesting object of further research. Pharmacology screening of active compound of medicinal plants would be time consumingExpand
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In silico and in vitro identification of candidate SIRT1 activators from Indonesian medicinal plants compounds database
TLDR
Sirtuin 1 (SIRT1) is a class III family of protein histone deacetylases involved in NAD+-dependent reactions. Expand
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Comparison of dopamine D 2 receptor ( homology model and X-ray structure ) and virtual screening protocol validation for the antagonism mechanism
The present research work aims to compare the homology model and recent X-ray crystal structure of dopamine D2 receptor (PDB Code: 6CM4) as well as to validate the virtual screening protocol forExpand
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HMG-CoA Reductase Inhibitory Activity of Gnetum gnemon Seed Extract and Identification of Potential Inhibitors for Lowering Cholesterol Level
Objectives: Melinjo (Gnetum gnemon) seeds have been known to have some biological properties. One of them is ant hypercholesterolemia. The present study investigated in vitro and in silico methods toExpand
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In silico Activity Analysis of Saponins and 2, 5-Piperazinedione from Marine Organism against Murine Double Minute-2 Inhibitor and Procaspase-3 Activator
Objective: Cancer is a disease that can occur because of apoptosis failure. One of the causes of apoptosis failure is the presence of MDM2 inhibiting the activity of p53 so procaspase-3 could not beExpand
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In Silico Approach to Finding New Active Compounds from Histone Deacetylase (HDAC) Family.
BACKGROUND Histone Deacetylase (HDAC) enzymes in the human body play an important role in the transcriptional regulation of gene expression. In the last decade, HDAC inhibitors and activators haveExpand
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Virtual screening of Indonesian herbal database as HIV-1 reverse transcriptase inhibitor
HIV-1 (Human immunodeficiency virus type 1) is a member of retrovirus family that could infect human and causing AIDS disease. AIDS epidemic is one of most destructive diseases in modern era. ThereExpand
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Virtual Screening of Indonesian Herbal Database as HIV-1 Protease Inhibitor
HIV-1 (Human immunodeficiency virus type 1)׳s infection is considered as one of most harmful disease known by human, the survivability rate of the host reduced significantly when it developed intoExpand
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Performance Analysis Cluster and GPU Computing Environment on Molecular Dynamic Simulation of BRV-1 and REM2 with GROMACS
TLDR
This paper reports our experiments that evaluate the performance of GROMACS that runs on two different environment, Cluster computing resources and GPU based PCs. Expand
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