Caspase activation during apoptotic cell death induced by expanded polyglutamine in N2a cells.
It is suggested that the cell death induced by expression of truncated N-terminal huntingtin with expanded polyglutamine is mediated by caspases.
Antimicrobial peptide LL-37 produced by HSV-2-infected keratinocytes enhances HIV infection of Langerhans cells.
- Y. Ogawa, T. Kawamura, S. Shimada
- BiologyCell Host and Microbe
- 16 January 2013
DICKKOPF‐4 and ‐2 genes are upregulated in human colorectal cancer
- A. Matsui, Tatsuya Yamaguchi, N. Enomoto
- Biology, MedicineCancer Science
- 1 October 2009
Dickkopf‐4 and ‐2 are significantly upregulated in most colorectal tumors, and that DickkopF‐4 upregulation reflects activation of the Wnt/canonical pathway.
Prevalence of drug-resistance-associated mutations in antiretroviral drug-naive Zambians infected with subtype C HIV-1.
- R. Handema, H. Terunuma, Masahiko Ito
- BiologyAIDS Research and Human Retroviruses
- 1 February 2003
Many naturally occurring polymorphisms in HIV-1 subtype C isolates from antiretroviral drug-naive individuals are revealed, which could lead to rapid treatment failure and development of drug-resistant HIV- 1 mutants in individuals undergoing antireTroviral therapy.
Human T‐cell leukemia virus type‐I Tax induces expression of interleukin‐6 receptor (IL‐6R): Shedding of soluble IL‐6R and activation of STAT3 signaling
- S. Horiuchi, Norio Yamamoto, N. Yamamoto
- Biology, MedicineInternational Journal of Cancer
- 15 August 2006
Human T‐cell leukemia virus type‐I (HTLV‐I) encodes for the viral protein Tax, which is known to significantly disrupt transcriptional control of cytokines, cytokine receptors and other…
Hallmarks of Hepatitis C Virus in Equine Hepacivirus
- Tomohisa Tanaka, H. Kasai, K. Moriishi
- BiologyJournal of Virology
- 10 September 2014
The results suggest that EHcV may conserve the genetic and biological properties of HCV, which shows the highest amino acid or nucleotide homology to HCV among hepaciviruses, was previously reported to infect horses from Western, but not Asian, countries.
Targeting lipid metabolism in the treatment of hepatitis C virus infection.
- F. Amemiya, S. Maekawa, N. Enomoto
- Biology, MedicineJournal of Infectious Diseases
- 1 February 2008
The data demonstrate that the sphingomyelin synthesis inhibitor strongly suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, indicating that lipid metabolism could be a novel target for HCV therapy.
Antithetical effects of hemicellulase‐treated Agaricus blazei on the maturation of murine bone‐marrow‐derived dendritic cells
- M. Kawamura, H. Kasai, Masahiko Ito
- Biology, MedicineImmunology
- 1 March 2005
ABH activated immature BMDCs, inducing up‐regulation of surface molecules, such as CD40, CD80 and major histocompatibility complex class I antigens, as well as inducing allogeneic T‐cell proliferation and T helper type 1 cell development.
Inhibition of hepatitis C virus NS3 helicase by manoalide.
- K. Salam, Atsushi Furuta, N. Akimitsu
- Biology, ChemistryJournal of Natural Products
- 6 March 2012
Manoalide (1) from marine sponge extracts is identified as an RNA helicase inhibitor using a high-throughput screening photoinduced electron transfer (PET) system and concludes that 1 inhibits the ATPase, RNA binding, and helicase activities of NS3 by targeting the helicase core domain conserved in both HCV NS3 and DHX36/RHAU.
Inhibition of Hepatitis C Virus Replication and Viral Helicase by Ethyl Acetate Extract of the Marine Feather Star Alloeocomatella polycladia
- A. Yamashita, K. Salam, K. Moriishi
- Biology, MedicineMarine Drugs
- 28 March 2012
Results suggest that the unknown compound(s) included in A. polycladia can inhibit HCV replication by suppressing the helicase activity of HCV NS3.
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