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C9orf72 is required for proper macrophage and microglial function in mice
It is found that two independent mouse lines lacking the C9orf72 ortholog in all tissues developed normally and aged without motor neuron disease, and altered microglial function may contribute to neurodegeneration in C 9orf72 expansion carriers. Expand
Gut microbiota promote hematopoiesis to control bacterial infection.
Findings reveal that gut bacteria direct innate immune cell development via promoting hematopoiesis, contributing to the appreciation of the deep evolutionary connection between mammals and their microbiota. Expand
Granulocyte‐Monocyte Progenitors and Monocyte‐Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes
SUMMARY Granulocyte‐monocyte progenitors (GMPs) and monocyte‐dendritic cell progenitors (MDPs) produce monocytes during homeostasis and in response to increased demand during infection. BothExpand
Influence of aging on murine neutrophil and macrophage function against Candida albicans.
The results indicate that murine phagocytes have a fungicidal activity well preserved with aging, and that the increased susceptibility to C. albicans disseminated infections in aged mice is correlated with defects in TLR2 expression and in cytokine production, but not with an impaired fungicide activity. Expand
ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis
It is suggested that OC2 displaces AR-dependent growth and survival mechanisms in many cases where AR remains expressed, but where its activity is bypassed, and is also a potential drug target in the metastatic phase of aggressive PC. Expand
IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production.
Roles for IRF8 are identified in regulating progenitor survival and differentiation and preventing leukemic cell accumulation, which shows it does not regulate granulocytic vs monocytic fate in GMPs, but instead acts downstream of lineage commitment to selectively control neutrophil and monocyte production. Expand
TLRs control hematopoiesis during infection
New insights demonstrate that TLR signaling in HSPCs, in addition to other TLR‐dependent mechanisms, can contribute to HSPC expansion and myeloid differentiation after infection. Expand
Direct Toll‐Like Receptor‐Mediated Stimulation of Hematopoietic Stem and Progenitor Cells Occurs In Vivo and Promotes Differentiation Toward Macrophages
It is shown, for the first time, that HSPCs may be directly stimulated by TLR agonists in vivo, and that the engagement of these receptors induces differentiation toward Mph, suggesting that H SPCs may sense pathogen or pathogen‐derived products directly during infection, inducing a rapid generation of cells of the innate immune system. Expand
Detection of a TLR2 agonist by hematopoietic stem and progenitor cells impacts the function of the macrophages they produce
In vitro and in vivo studies show that macrophages derived from mouse and human HSPC subsets exposed to a TLR2 agonist prior to or during macrophage differentiation produce lower levels of inflammatory cytokines and reactive oxygen species, and this may impact the clinical utility of targeting TLRs on HSPCs to boost myelopoiesis. Expand
C9orf72 in myeloid cells suppresses STING-induced inflammation
It is suggested that patients with C9-ALS/FTD have an altered immunophenotype because their reduced levels of C9orf72 cannot suppress the inflammation mediated by the induction of type I interferons by STING. Expand