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Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
Research on fluorescent semiconductor nanocrystals (also known as quantum dots or qdots) has evolved over the past two decades from electronic materials science to biological applications. We review… Expand
Arming antibodies: prospects and challenges for immunoconjugates
Immunoconjugates—monoclonal antibodies (mAbs) coupled to highly toxic agents, including radioisotopes and toxic drugs (ineffective when administered systemically alone)—are becoming a significant… Expand
Consensus guided mutagenesis of Renilla luciferase yields enhanced stability and light output.
- A. Loening, T. Fenn, A. Wu, S. Gambhir
- Biology, Medicine
- Protein engineering, design & selection : PEDS
- 1 September 2006
Luciferases, which have seen expansive employment as reporter genes in biological research, could also be used in applications where the protein itself is conjugated to ligands to create probes that… Expand
The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry.
Virus entry into cells is typically initiated by binding of virally encoded envelope proteins to specific cell surface receptors. Studying infectivity of lentivirus pseudotypes lacking envelope… Expand
Minibody: A novel engineered anti-carcinoembryonic antigen antibody fragment (single-chain Fv-CH3) which exhibits rapid, high-level targeting of xenografts.
A novel engineered antibody fragment (VL-VH-CH3, or "minibody") with bivalent binding to carcinoembryonic antigen (CEA) was produced by genetic fusion of a T84.66 (anti-CEA) single-chain antibody… Expand
Particle size, surface coating, and PEGylation influence the biodistribution of quantum dots in living mice.
This study evaluates the influence of particle size, PEGylation, and surface coating on the quantitative biodistribution of near-infrared-emitting quantum dots (QDs) in mice. Polymer- or… Expand
Effects of probiotic-supplemented diets on growth performance and intestinal immune characteristics of broiler chickens.
This study was conducted to investigate the effects of a probiotic product incorporating Lactobacillus fermentum and Saccharomyces cerevisiae on the growth performance and intestinal immune status in… Expand
A cytological study of the capacity for differentiation of normal hemopoietic colony‐forming cells
- A. Wu, J. Till, L. Siminovitch, E. Mcculloch
- Biology, Medicine
- Journal of cellular physiology
- 1 April 1967
A two‐stage procedure has been used to obtain hemopoietic spleen colonies derived from single precursor cells containing radiation‐induced chromosomal markers. Of a total of 46 colonies examined, 17… Expand
Optical bioluminescence and positron emission tomography imaging of a novel fusion reporter gene in tumor xenografts of living mice.
Noninvasive imaging of reporter gene expression using various imaging modalitiesis playing an increasingly important role in defining molecular events in the field of cancer biology, cell biology,… Expand
A Predictive Model of Therapeutic Monoclonal Antibody Dynamics and Regulation by the Neonatal Fc Receptor (FcRn)
We constructed a novel physiologically-based pharmacokinetic (PBPK) model for predicting interactions between the neonatal Fc receptor (FcRn) and anti-carcinoembryonic antigen (CEA) monoclonal… Expand