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Brain slices as models for neurodegenerative disease and screening platforms to identify novel therapeutics.
Recent improvements in brain slice technology have made this biological preparation increasingly useful for examining pathophysiology of brain diseases in a tissue context. Brain slices maintain manyExpand
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Review: Glial lineages and myelination in the central nervous system
Oligodendrocytes, derived from stem cell precursors which arise in subventricular zones of the developing central nervous system, have as their specialist role the synthesis and maintenance ofExpand
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Glial lineages and myelination in the central nervous system.
Oligodendrocytes, derived from stem cell precursors which arise in subventricular zones of the developing central nervous system, have as their specialist role the synthesis and maintenance ofExpand
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Novel Agonist Monoclonal Antibodies Activate TrkB Receptors and Demonstrate Potent Neurotrophic Activities
Tyrosine kinase receptor B (TrkB) mediates neurotrophic effects of brain-derived neurotrophic factor (BDNF) to increase neuronal survival, differentiation, synaptic plasticity, and neurogenesis. TheExpand
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Developmental regulation of neurogenesis in the pluripotent human embryonal carcinoma cell line NTERA‐2
Embryonal carcinoma (EC) cells provide a caricature of pluripotent embryonic stem (ES) cells and may be used as surrogates for investigating the mechanisms that regulate cell differentiation duringExpand
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Transcriptional Profiling of Neuronal Differentiation by Human Embryonal Carcinoma Stem Cells In Vitro
Pluripotent stem cell lines can be induced to differentiate into a range of somatic cell types in response to various stimuli. Such cell‐based systems provide powerful tools for the investigation ofExpand
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Guidance of oligodendrocytes and their progenitors by substratum topography.
Oligodendrocyte progenitors arise in subventricular zones and migrate extensively during development before differentiating into mature oligodendrocytes, which myelinate nerve tracts in the centralExpand
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Mucin-Inspired Thermoresponsive Synthetic Hydrogels Induce Stasis in Human Pluripotent Stem Cells and Human Embryos
Human pluripotent stem cells (hPSCs; both embryonic and induced pluripotent) rapidly proliferate in adherent culture to maintain their undifferentiated state. However, for mammals exhibiting delayedExpand
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Section Review Central & Peripheral Nervous Systems: Mechanisms of apoptosis as drug targets in the central nervous system
Programmed cell death or apoptosis describes a process whereby cells actively commit to die. Under normal conditions, it is likely that apoptosis is required for embryogenesis, immune system functionExpand
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Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions
The occurrence of repetitive genomic changes that provide a selective growth advantage in pluripotent stem cells is of concern for their clinical application. However, the effect of different cultureExpand
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