Maternal Immune Activation during Gestation Interacts with Disc1 Point Mutation to Exacerbate Schizophrenia-Related Behaviors in Mice
- T. Lipina, C. Zai, D. Hlousek, J. Roder, A. Wong
- Biology, PsychologyJournal of Neuroscience
- 1 May 2013
Coadministration of an anti-IL-6 antibody with polyI:C reversed schizophrenia-related behavioral phenotypes in Disc1-L100P+/− mice, suggesting IL-6 may be important in the pathophysiology of this interaction.
Herbal remedies in psychiatric practice.
In many cases the quantity and quality of data were insufficient to make definitive conclusions about efficacy or safety, but there was good evidence for the efficacy of St John's wort for the treatment of depression and for ginkgo in the Treatment of memory impairment caused by dementia.
Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model.
Analysis of SRR genetic variants in humans identified a robust association with schizophrenia and demonstrates that aberrant Srr function and diminished d-serine may contribute to schizophrenia pathogenesis.
Polymorphisms in dopamine receptors: what do they tell us?
N-methyl-d-aspartate receptor NR2B subunit gene GRIN2B in schizophrenia and bipolar disorder: Polymorphisms and mRNA levels
A Dopamine D2 Receptor-DISC1 Protein Complex may Contribute to Antipsychotic-Like Effects
Social defeat interacts with Disc1 mutations in the mouse to affect behavior
Interactions between NMDA and dopamine receptors: A potential therapeutic target
Contributions of the d-serine pathway to schizophrenia
Evidence of Association between Smoking and α7 Nicotinic Receptor Subunit Gene in Schizophrenia Patients
- V. Luca, A. Wong, D. Muller, G. Wong, R. Tyndale, J. Kennedy
- Psychology, MedicineNeuropsychopharmacology
- 1 August 2004
This study hypothesized that the D15S1360 marker is associated with smoking in patients with schizophrenia and found an association between the homozygous 113 bp allele and smoking risk (χ2=10.37, 3 df, p=0.015), suggesting that further study into the relationship between schizophrenia and nicotine system genes is warranted.