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Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms.
- S. Larsson, M. Kumlin, M. Ingelman-Sundberg, A. Wolk
- Biology, Medicine
- The American journal of clinical nutrition
- 1 June 2004
Several molecular mechanisms whereby n-3 fatty acids may modify the carcinogenic process have been proposed, and influences on transcription factor activity, gene expression, and signal transduction pathways; alteration of estrogen metabolism; increased or decreased production of free radicals and reactive oxygen species; and mechanisms involving insulin sensitivity and membrane fluidity are proposed. Expand
Diabetes mellitus and risk of colorectal cancer: a meta-analysis.
A meta-analysis of published data on the association between diabetes and the incidence and mortality of colorectal cancer found that diabetes was associated with an increased risk of colors, compared with no diabetes, and these results were consistent between case-control and cohort studies and between studies conducted in the United States and in Europe. Expand
Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk.
- P. A. van den Brandt, D. Spiegelman, +15 authors D. Hunter
- Medicine, Chemistry
- American journal of epidemiology
- 15 September 2000
The authors found little evidence for interaction with other breast cancer risk factors, and data indicate that height is an independent risk factor for postmenopausal breast cancer; in premenopausal women, this relation is less clear. Expand
A prospective study of obesity and cancer risk (Sweden)
Obesity is associated with more forms of cancer than previously reported and the association of obesity with risk of breast, prostate and pancreas cancers was modified by age. Expand
Association of Leisure-Time Physical Activity With Risk of 26 Types of Cancer in 1.44 Million Adults.
Leisure-time physical activity was associated with lower risks of many cancer types, and most of these associations were evident regardless of body size or smoking history, supporting broad generalizability of findings. Expand
Association analysis identifies 65 new breast cancer risk loci
A genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry finds that heritability of Breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2–5-fold enriched relative to the genome- wide average. Expand
Meat consumption and risk of colorectal cancer: A meta‐analysis of prospective studies
Results of this meta‐analysis of prospective studies support the hypothesis that high consumption of red meat and of processed meat is associated with an increased risk of colorectal cancer. Expand
Overweight as an avoidable cause of cancer in Europe
- A. Bergström, P. Pisani, V. Tenet, A. Wolk, H. Adami
- International journal of cancer
- 1 February 2001
Excess body mass accounts for 5% of all cancers in the European Union, 3% in men and 6% in women, corresponding to 27,000 male and 45,000 female cancer cases yearly, and can be avoided by halving the prevalence of overweight and obese people in Europe. Expand
Alcohol and breast cancer in women: a pooled analysis of cohort studies.
Alcohol consumption is associated with a linear increase in breast cancer incidence in women over the range of consumption reported by most women, and reducing alcohol consumption is a potential means to reduce breast cancer risk. Expand
Meta-analysis for linear and nonlinear dose-response relations: examples, an evaluation of approximations, and software.
- N. Orsini, R. Li, A. Wolk, Polyna Khudyakov, D. Spiegelman
- Computer Science, Medicine
- American journal of epidemiology
Methods for point and interval estimation of relative risk for log-linear exposure-response relations in meta-analyses of published ordinal categorical exposure- response data have been proposed and the use of 2 publicly available user-friendly programs (Stata and SAS) to implement meta-analysis for dose-response data is illustrated. Expand