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Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [N-11C-Methyl]-(−)-Cocaine PET Studies in Human Subjects
A graphical method of analysis applicable to ligands that bind reversibly to receptors or enzymes requiring the simultaneous measurement of plasma and tissue radioactivities for multiple times afterExpand
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Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers
Decreased dopaminergic function has been postulated to underlie cocaine addiction. To examine the possibility that dysfunction of brain regions subserved by the dopamine system could promote cocaineExpand
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Changes in brain glucose metabolism in cocaine dependence and withdrawal.
OBJECTIVE The authors investigated changes in brain function associated with cocaine dependence and withdrawal to provide clues regarding the processes that lead to the uncontrollableExpand
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Long‐Term frontal brain metabolic changes in cocaine abusers
Neurological complications from cocaine use are well recognized. We propose that chronic cocaine use can also cause clinically silent brain dysfunction.
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Striatal binding of the PET ligand 11C‐raclopride is altered by drugs that modify synaptic dopamine levels
Bilatera decreases in striatal 11C‐raclopride binding were observed in adult female baboons with high resolution PET following administration of drugs that act centrally on dopaminergic neurons. AtExpand
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Metabolic trapping as a principle of oradiopharmaceutical design: some factors resposible for the biodistribution of [18F] 2-deoxy-2-fluoro-D-glucose.
Initially, [18F]2-deoxy-2-fluoro-D-glucose (F-18-DG) distributes to the kid neys, heart, brain, lungs, and liver of the mouse, and clears rapidly from all except the heart and, to a much lesserExpand
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Mapping human brain monoamine oxidase A and B with 11C-labeled suicide inactivators and PET.
The regional distributions of monoamine oxidase (MAO) types A and B have been identified in human brain in vivo with intravenously injected 11C-labeled suicide enzyme inactivators, clorgyline andExpand
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Decreased dopamine transporters with age in healthy human subjects
The effects of aging on brain dopamine transporters was evaluated in 26 healthy male volunteers (age range, 21–63 years) using positron emission tomography and [11C]cocaine. The ratio of theExpand
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GABAergic inhibition of endogenous dopamine release measured in vivo with 11C-raclopride and positron emission tomography
  • S. Dewey, G. Smith, +7 authors A. Wolf
  • Chemistry, Medicine
  • The Journal of neuroscience : the official…
  • 1 October 1992
Extensive neuroanatomical, neurophysiological, and behavioral evidence demonstrates that GABAergic neurons inhibit endogenous dopamine release in the mammalian corpus striatum. Positron emissionExpand
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The radiation dosimetry of 2 [F-18]fluoro-2-deoxy-D-glucose in man.
Bladder and brain time-activity measurements in humans were performed after the intravenous administration of 2-[F-18]fluoro-2-deoxy-D-glucose. Radiation doses were calculated using the MIRD schema.Expand
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