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Oxidative stress-mediated induction of MMP-1 and MMP-3 in human RPE cells.
PURPOSE In early exudative age-related macular degeneration (AMD), segmental thinning of Bruch's membrane is associated with ingrowth of choroidal neovascularization into the subretinal space. ToExpand
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Imatinib does not induce cardiotoxicity at clinically relevant concentrations in preclinical studies.
Cytotoxic concentrations of imatinib mesylate (10-50 microM) were required to trigger markers of apoptosis and endoplasmic reticulum stress response in neonatal rat ventricular myocytes andExpand
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Phase II Metabolism in Human Skin: Skin Explants Show Full Coverage for Glucuronidation, Sulfation, N-Acetylation, Catechol Methylation, and Glutathione Conjugation
Although skin is the largest organ of the human body, cutaneous drug metabolism is often overlooked, and existing experimental models are insufficiently validated. This proof-of-concept studyExpand
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Reduced Activity of Sphingosine-1-Phosphate Lyase Induces Podocyte-related Glomerular Proteinuria, Skin Irritation, and Platelet Activation
Sphingosine-1-phosphate (S1P) lyase is considered as a drug target in autoimmune diseases based on the protective effect of reducing activity of the enzyme in animal models of inflammation. Since S1PExpand
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Inhibition of TLR3-mediated proinflammatory effects by Alkylphosphocholines in human retinal pigment epithelial cells.
PURPOSE. To elucidate the role of Toll-like receptor 3 (TLR3) in the pathogenesis of age-related macular degeneration (AMD) and to investigate the effect of alkylphosphocholines (APCs) on theExpand
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Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11β-hydroxysteroid dehydrogenase 1.
The oxidized bile acid 7-oxoLCA (7-oxolithocholic acid), formed primarily by gut micro-organisms, is reduced in human liver to CDCA (chenodeoxycholic acid) and, to a lesser extent, UDCAExpand
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Preclinical evaluation of potential nilotinib cardiotoxicity.
In vitro, concentrations ≥ 10 μM of nilotinib were needed to induce markers of cytotoxicity, apoptosis, and endoplasmic reticulum stress in both neonatal rat ventricular myocytes, a putative targetExpand
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Mechanistic insights into selective killing of OXPHOS-dependent cancer cells by arctigenin.
Arctigenin has previously been identified as a potential anti-tumor treatment for advanced pancreatic cancer. However, the mechanism of how arctigenin kills cancer cells is not fully understood. InExpand
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The Ebstorf Mappamundi and Gervase of Tilbury: The Controversy Revisited
ABSTRACT The date of the Ebstorf world map, whether it originated early (between 1208 and 1250) or late (around 1300), has been controversial for decades. In the case of the earlier dates, Gervase ofExpand
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What can the history of historical atlases teach? Some lessons from a century of putzger's 'historischer schul-atlas'
The history of cartography lacks an important chapter, namely, the history of historical atlases. The observations presented here are based on an analysis of 100 editions of Putzger's HistorischerExpand
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