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DSulfatase-1 fine-tunes Hedgehog patterning activity through a novel regulatory feedback loop.
Sulfs are secreted sulfatases that catalyse removal of sulfate from Heparan Sulfate Proteoglycans (HSPGs) in the extracellular space. These enzymes are well known to regulate a number of crucialExpand
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Robustness of positional specification by the Hedgehog morphogen gradient.
Spatial gradients of Hedgehog signalling play a central role in many patterning events during animal development, regulating cell fate determination and tissue growth in a variety of tissues andExpand
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