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5-HT7R/G12 Signaling Regulates Neuronal Morphology and Function in an Age-Dependent Manner
The common neurotransmitter serotonin controls different aspects of early neuronal differentiation, although the underlying mechanisms are poorly understood. Here we report that activation of theExpand
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Dual lipidation of the brain-specific Cdc42 isoform regulates its functional properties.
Cdc42 (cell division cycle 42) is a member of the Rho GTPase family which regulates a variety of cellular activities by controlling actin cytoskeleton and gene expression. Cdc42 is expressed in theExpand
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Cellular mechanisms of the 5-HT7 receptor-mediated signaling
Serotonin (5-hydroxytryptamine or 5-HT) is an important neurotransmitter regulating a wide range of physiological and pathological functions via activation of heterogeneously expressed 5-HTExpand
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Cdc42: an important regulator of neuronal morphology.
Regulation of neuronal morphology and activity-dependent synaptic modifications involves reorganization of the actin cytoskeleton. Dynamic changes of the actin cytoskeleton in many cell types areExpand
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How serotonin receptors regulate morphogenic signalling in neurons
HighlightsSerotonin (5‐HT) is critically involved in the regulation of multiple physiological and pathophysiological functions in the CNS.5‐HT operates via a heterogenic receptor family comprisingExpand
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Palmitoylation of cdc42 Promotes Spine Stabilization and Rescues Spine Density Deficit in a Mouse Model of 22q11.2 Deletion Syndrome
22q11.2 deletion syndrome (22q11DS) is associated with learning and cognitive dysfunctions and a high risk of developing schizophrenia. It has become increasingly clear that dendritic spineExpand
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The effect of experimental balancing interferences on masticatory performance.
Immediate adaptation to experimental-balancing interferences is known to affect jaw kinematics and electromyographic activity (EMG). However, little is known about the influence on masticatoryExpand
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Computational and Experimental Analysis of the Transmembrane Domain 4/5 Dimerization Interface of the Serotonin 5-HT1A Receptor
Experimental evidence suggests that most members of class A G-protein coupled receptors (GPCRs) can form homomers and heteromers in addition to functioning as single monomers. In particular,Expand
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Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors
The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are implicated in major depressive disorder (MDD). Here we demonstrated that 5-HT1AR is palmitoylated in human and rodentExpand
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Effect of the occlusal profile on the masticatory performance of healthy dentate subjects.
PURPOSE The purpose of this study was to examine, on the basis of masticatory performance (MP), total muscle work (TMW), and range of movement (RoM), whether reduction of the profile of the cuspsExpand
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