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Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer
TLDR
The authors assess the clinical toxicity, safety and quality of non-invasive imaging of PD-1 and PD-L1 expression in 13 patients with advanced lung cancer prior to treatment with immunotherapy and show it correlates with response. Expand
Δ9-Tetrahydrocannabinol Induces Dopamine Release in the Human Striatum
TLDR
It is shown that Δ9-tetrahydrocannabinol (THC), the main psychoactive component in cannabis, induces dopamine release in the human striatum, implying that the endogenous cannabinoid system is involved in regulating striatal dopamine release. Expand
Blood-brain barrier P-glycoprotein function in Alzheimer's disease.
TLDR
Assessment of blood-brain barrier P-glycoprotein function in patients with Alzheimer's disease compared with age-matched healthy controls shows altered kinetics of (R)-[(11)C]verapamil in Alzheimer’s disease, similar to alterations seen in studies where P- glycoprotein is blocked by a pharmacological agent. Expand
Relationship of Cerebrospinal Fluid Markers to 11C-PiB and 18F-FDDNP Binding
TLDR
The good agreement between these 2 different types of biomarkers (i.e., CSF and PET) provides converging evidence for their validity and suggests that at least part of the specific signal of 18F-FDDNP in AD patients is due to tangle formation. Expand
Evaluation of Tracer Kinetic Models for Quantification of P-Glycoprotein Function using (R)-[11C]Verapamil and PET
TLDR
The aim of the present study was to evaluate the kinetics of pure (R)-[11C]verapamil in humans and to develop a tracer kinetic model for the analysis of P-gp-mediated transport of (R), including the putative contribution of its radioactive metabolites. Expand
Detection of Alzheimer Pathology In Vivo Using Both 11C-PIB and 18F-FDDNP PET
TLDR
The difference in regional binding, the moderate correlation, and the discrepant findings in MCI suggest that they measure related, but different, characteristics of the disease. Expand
Development of a Tracer Kinetic Plasma Input Model for (R)-[11C]PK11195 Brain Studies
TLDR
It was concluded that a two-tissue reversible compartment model with K1/k2 fixed to whole cortex value is optimal for analyzing (R)-[11C]PK11195 PET brain studies. Expand
Microglia Activation in Recent-Onset Schizophrenia: A Quantitative (R)-[11C]PK11195 Positron Emission Tomography Study
TLDR
Activated microglia are present in schizophrenia patients within the first 5 years of disease onset, which suggests that, in this period, neuronal injury is present and that neuronal damage may be involved in the loss of gray matter associated with this disease. Expand
Impact of molecular imaging on the diagnostic process in a memory clinic
TLDR
PIB and FDG PET measure fibrillar amyloid‐β load and glucose metabolism, respectively, and the impact of these tracers on the diagnostic process in a memory clinic population is evaluated. Expand
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